{"entity":{"id":"l3mbtl3","kind":"target","name":"L3MBTL3","aka":["L3MBTL histone methyl-lysine binding protein 3","Lethal(3)malignant brain tumor-like protein 3","KIAA1798"],"tldr":"L3MBTL3 (Lethal(3)malignant brain tumour-like protein 3) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.","summary":"Is a negative regulator of Notch target genes expression, required for RBPJ-mediated transcriptional repression. It recruits KDM1A to Notch-responsive elements and promotes KDM1A-mediated H3K4me demethylation. Involved in the regulation of ubiquitin-dependent degradation of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1.\n\nOpen Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.81, genetic association 0.67).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:23035","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:23035"},{"label":"UniProt Q96JM7","url":"https://www.uniprot.org/uniprotkb/Q96JM7/entry"},{"label":"NCBI Gene 84456","url":"https://www.ncbi.nlm.nih.gov/gene/84456"},{"label":"Ensembl ENSG00000198945","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000198945"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["breast-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"L3MBTL3","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:23035","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:23035","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q96JM7","url":"https://www.uniprot.org/uniprotkb/Q96JM7/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000198945","url":"https://platform.opentargets.org/target/ENSG00000198945/associations","note":"association with cancer (MONDO_0004992) 0.54; per-cancer scores at or above 0.5: breast cancer 0.51 (GraphQL API, CC0)"}],"specificitySources":[],"hgnc":"HGNC:23035","ensembl":"ENSG00000198945","uniprot":"Q96JM7","entrez":"84456","firstDescribed":2001,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 2001, \"Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/11347906/","biology":"Is a negative regulator of Notch target genes expression, required for RBPJ-mediated transcriptional repression. It recruits KDM1A to Notch-responsive elements and promotes KDM1A-mediated H3K4me demethylation. Involved in the regulation of ubiquitin-dependent degradation of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1. It acts as an adapter recruiting the CRL4-DCAF5 E3 ubiquitin ligase complex to methylated target proteins. Required for normal maturation of myeloid progenitor cells. Location: Nucleus (UniProt). Locus 6q23.1 (HGNC).","whereFound":["Breast cancer: Open Targets association 0.51 with breast cancer (MONDO_0007254)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/l3mbtl3/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"}]}}