{"entity":{"id":"kymera","kind":"company","name":"Kymera Therapeutics","aka":[],"tldr":"Oral degrader company, mostly immunology, whose CDK2 molecular-glue degrader was optioned by Gilead in 2026 for CCNE1-driven cancers.","summary":"Kymera Therapeutics, based in Watertown, Massachusetts, and listed as KYMR, is an oral protein degrader company focused mostly on immunology, whose CDK2 molecular-glue degrader was optioned by Gilead in 2026 for CCNE1-driven cancers. Gilead paid 40 million dollars for an option in June 2025 and exercised it for 45 million dollars in April 2026 on the preclinical CDK2 glue degrader KT-200, aimed at CCNE1-amplified tumours and resistance to CDK4/6 inhibitors, while Kymera's own clinical pipeline against IRAK4, STAT6 and TYK2 is immunological. OnCo links it to ovarian and HR-positive breast cancer, to PROTACs and molecular glues and glue discovery platforms, to CDK4/6 as a target, to Gilead, and to ideas including glues that break the MYC-MAX partnership. The undruggable drivers are the bottleneck it bears on. Whether CDK2 degradation is tolerable is the open question.","asOf":"2026-09-04","links":[{"label":"Gilead option exercise","url":"https://www.fiercebiotech.com/biotech/gilead-pays-kymera-45m-glue-preclinical-protein-degrader-burgeoning-oncology-pipeline"}],"tags":[],"related":["src-fierce-biotech"],"cancers":["ovarian","breast-hr-positive"],"sections":["targeted-therapy"],"technologies":["protac-degrader"],"targets":["cdk4-6"],"drugs":[],"companies":["gilead"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"hq":"Watertown, MA","country":"US","companyType":"biotech","website":"https://www.kymeratx.com","ticker":"KYMR","investors":[],"funding":[]},"route":"/companies/kymera/","neighbours":{"collection":[{"id":"src-fierce-biotech","kind":"collection","name":"Fierce Biotech","route":"/collections/src-fierce-biotech/"}],"cancer":[{"id":"breast-hr-positive","kind":"cancer","name":"HR-positive / HER2-negative breast cancer","route":"/cancers/breast-hr-positive/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"}],"section":[{"id":"targeted-therapy","kind":"section","name":"Targeted Therapy","route":"/fronts/targeted-therapy/"}],"technology":[{"id":"molecular-glue-platforms","kind":"technology","name":"Molecular glue discovery platforms","route":"/technologies/molecular-glue-platforms/"},{"id":"protac-degrader","kind":"technology","name":"PROTACs & molecular glues (targeted protein degradation)","route":"/technologies/protac-degrader/"}],"target":[{"id":"cdk4-6","kind":"target","name":"CDK4/6","route":"/targets/cdk4-6/"}],"company":[{"id":"gilead","kind":"company","name":"Gilead Sciences (incl. Kite)","route":"/companies/gilead/"}],"bottleneck":[{"id":"b-undruggable-targets","kind":"bottleneck","name":"The undruggable drivers","route":"/bottlenecks/b-undruggable-targets/"}],"idea":[{"id":"idea-moon-open-degrader-consortium","kind":"idea","name":"An open degrader consortium against every undruggable driver transcription factor","route":"/ideas/idea-moon-open-degrader-consortium/"},{"id":"idea-bio2-brain-penetrant-glue-degraders","kind":"idea","name":"Design protein degraders small enough to get into the brain","route":"/ideas/idea-bio2-brain-penetrant-glue-degraders/"},{"id":"idea-bio1-tumour-restricted-e3-atlas","kind":"idea","name":"Find E3 ligases that only tumours have, and build degraders around them","route":"/ideas/idea-bio1-tumour-restricted-e3-atlas/"},{"id":"idea-bio1-myc-max-molecular-glue","kind":"idea","name":"Molecular glues that break the MYC-MAX partnership","route":"/ideas/idea-bio1-myc-max-molecular-glue/"},{"id":"idea-bio1-glue-degrader-atlas","kind":"idea","name":"Screen glue-like compounds against every cancer cell line and publish it","route":"/ideas/idea-bio1-glue-degrader-atlas/"},{"id":"idea-bio1-antibody-degrader-conjugates","kind":"idea","name":"Use antibodies to deliver protein-destroying drugs into the right cells","route":"/ideas/idea-bio1-antibody-degrader-conjugates/"}]}}