{"entity":{"id":"klln","kind":"target","name":"KLLN","aka":["killin, p53 regulated DNA replication inhibitor","Killin","killin"],"tldr":"KLLN (Killin) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer and Renal cell carcinoma.","summary":"DNA-binding protein involved in S phase checkpoint control-coupled apoptosis by mediating p53/TP53-induced apoptosis. Has the ability to inhibit DNA synthesis and S phase arrest coupled to apoptosis. Has affinity to both double- and single-stranded DNA.\n\nCIViC holds 2 clinical evidence items and 0 assertions across 1 variant.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:37212","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:37212"},{"label":"UniProt B2CW77","url":"https://www.uniprot.org/uniprotkb/B2CW77/entry"},{"label":"NCBI Gene 100144748","url":"https://www.ncbi.nlm.nih.gov/gene/100144748"},{"label":"Ensembl ENSG00000227268","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000227268"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["breast-cancer","rcc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 2 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"KLLN","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:37212","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:37212","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt B2CW77","url":"https://www.uniprot.org/uniprotkb/B2CW77/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene KLLN","url":"https://civicdb.org/features/32083","note":"2 evidence items, 0 assertions, 1 variants; diseases: Breast Cancer, Renal Cell Carcinoma (GraphQL API, CC0)"}],"distribution":"few-types","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA KLLN: RNA tissue enhanced (skeletal muscle 4 nTPM); no normal tissue stained high. Distribution: 2 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Breast cancer (all types), Renal cell carcinoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas KLLN tissue","url":"https://www.proteinatlas.org/ENSG00000227268-KLLN/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000227268 associations","url":"https://platform.opentargets.org/target/ENSG00000227268/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:37212","ensembl":"ENSG00000227268","uniprot":"B2CW77","entrez":"100144748","firstDescribed":2004,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Deloukas et al, Nature, 2004, \"The DNA sequence and comparative analysis of human chromosome 10\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/15164054/","biology":"DNA-binding protein involved in S phase checkpoint control-coupled apoptosis by mediating p53/TP53-induced apoptosis. Has the ability to inhibit DNA synthesis and S phase arrest coupled to apoptosis. Has affinity to both double- and single-stranded DNA. Location: Nucleus (UniProt). Locus 10q23 (HGNC).","whereFound":["Breast cancer: CIViC evidence names this disease","Renal cell carcinoma: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/klln/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"rcc","kind":"cancer","name":"Renal cell carcinoma","route":"/cancers/rcc/"}]}}