{"entity":{"id":"kif5b","kind":"target","name":"KIF5B","aka":["kinesin family member 5B","Kinesin-1 heavy chain","uKHC","KNS1"],"tldr":"KIF5B (Kinesin-1 heavy chain) is a gene that drives cell growth when it is altered. The public catalogues list it as a drug target and an oncogene driver, and an approved or late-stage drug is recorded against it. Tied to Lung cancer, Thyroid cancer, Neuroendocrine tumours and 2 more.","summary":"Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. Regulates centrosome and nuclear positioning during mitotic entry.\n\nOpen Targets scores its association with cancer at 0.81 (direct and indirect evidence; datatypes clinical 0.97, affected pathway 0.93, literature 0.91, genetic association 0.00, somatic mutation 0.82). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Head and Neck Squamous Cell Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6324","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6324"},{"label":"UniProt P33176","url":"https://www.uniprot.org/uniprotkb/P33176/entry"},{"label":"NCBI Gene 3799","url":"https://www.ncbi.nlm.nih.gov/gene/3799"},{"label":"Ensembl ENSG00000170759","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000170759"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["lung-cancer","thyroid","neuroendocrine","head-and-neck","nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.97; IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"KIF5B","role":["drug-target","oncogene-driver"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:6324","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6324","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P33176","url":"https://www.uniprot.org/uniprotkb/P33176/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000170759","url":"https://platform.opentargets.org/target/ENSG00000170759/associations","note":"association with cancer (MONDO_0004992) 0.81; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.72, thyroid cancer 0.64, neuroendocrine neoplasm 0.63, lung cancer 0.73 (GraphQL API, CC0)"},{"label":"IntOGen KIF5B","url":"https://www.intogen.org/search?gene=KIF5B","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"specificity":"tumour-specific","distribution":"few-types","specificityNote":"Tumour-specific alteration: the catalogues call it an oncogene driver (IntOGen cohort analysis finds it activated more often than chance); what a medicine would aim at or exploit is the altered form or its loss, absent from normal cells; no corpus medicine is aimed at it yet. HPA KIF5B: RNA low tissue specificity; high antibody staining in 19 normal tissues; highest cancer staining pancreatic cancer (7 of 11 high). Distribution: 4 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Lung cancer (all types), Thyroid cancer, Neuroendocrine tumours, Head and neck squamous cell carcinoma); Open Targets associates it with 2 specific cancer types at or above 0.5 (non-small cell lung carcinoma, medullary thyroid gland carcinoma). (Rule 6 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"UniProt P33176","url":"https://www.uniprot.org/uniprotkb/P33176/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen KIF5B","url":"https://www.intogen.org/search?gene=KIF5B","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"},{"label":"Human Protein Atlas KIF5B tissue","url":"https://www.proteinatlas.org/ENSG00000170759-KIF5B/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000170759 associations","url":"https://platform.opentargets.org/target/ENSG00000170759/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:6324","ensembl":"ENSG00000170759","uniprot":"P33176","entrez":"3799","firstDescribed":1992,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Navone et al, J. Cell Biol, 1992, \"Cloning and expression of a human kinesin heavy chain gene: interaction of the COOH-terminal domain with cytoplasmic microtubules in transfected CV-1 cells\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/1607388/","biology":"Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonises dynein function and drives the separation of nuclei and centrosomes. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation. Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends. Location: Cytoplasm, cytoskeleton; Cytolytic granule membrane; Lysosome membrane (UniProt). Locus 10p11.22 (HGNC).","whereFound":["Lung cancer: Open Targets association 0.73 with lung cancer (MONDO_0008903)","Thyroid cancer: Open Targets association 0.64 with thyroid cancer (MONDO_0002108)","Neuroendocrine tumours: Open Targets association 0.63 with neuroendocrine neoplasm (MONDO_0019496)","Head and neck squamous cell carcinoma: IntOGen driver in 1 cohort (HNSC)","Non-small-cell lung cancer: Open Targets association 0.72 with non-small cell lung carcinoma (MONDO_0005233)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/kif5b/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"neuroendocrine","kind":"cancer","name":"Neuroendocrine tumours","route":"/cancers/neuroendocrine/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"thyroid","kind":"cancer","name":"Thyroid cancer","route":"/cancers/thyroid/"}]}}