{"entity":{"id":"kiaa1549","kind":"target","name":"KIAA1549","aka":["UPF0606 protein KIAA1549"],"tldr":"KIAA1549 (UPF0606 protein KIAA1549) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.","summary":"May play a role in photoreceptor function.\n\nOpen Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.25, affected pathway 0.89, genetic association 0.00, somatic mutation 0.50).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:22219","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:22219"},{"label":"UniProt Q9HCM3","url":"https://www.uniprot.org/uniprotkb/Q9HCM3/entry"},{"label":"NCBI Gene 57670","url":"https://www.ncbi.nlm.nih.gov/gene/57670"},{"label":"Ensembl ENSG00000122778","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000122778"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":["firefly-1"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"KIAA1549","role":["fusion-partner"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:22219","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:22219","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9HCM3","url":"https://www.uniprot.org/uniprotkb/Q9HCM3/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000122778","url":"https://platform.opentargets.org/target/ENSG00000122778/associations","note":"association with cancer (MONDO_0004992) 0.62;  (GraphQL API, CC0)"}],"specificitySources":[],"hgnc":"HGNC:22219","ensembl":"ENSG00000122778","uniprot":"Q9HCM3","entrez":"57670","firstDescribed":2000,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 2000, \"Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/10997877/","biology":"May play a role in photoreceptor function. Location: Membrane; Cell projection, cilium (UniProt). Locus 7q34 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/kiaa1549/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"trial":[{"id":"firefly-1","kind":"trial","name":"FIREFLY-1","route":"/trials/firefly-1/"}]}}