{"entity":{"id":"kdm5d","kind":"target","name":"KDM5D","aka":["lysine demethylase 5D","Lysine-specific demethylase 5D","KIAA0234","JARID1D"],"tldr":"KDM5D (Lysine-specific demethylase 5D) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer.","summary":"Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Berzosertib.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11115","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11115"},{"label":"UniProt Q9BY66","url":"https://www.uniprot.org/uniprotkb/Q9BY66/entry"},{"label":"NCBI Gene 8284","url":"https://www.ncbi.nlm.nih.gov/gene/8284"},{"label":"Ensembl ENSG00000012817","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000012817"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["prostate"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"KDM5D","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:11115","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11115","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9BY66","url":"https://www.uniprot.org/uniprotkb/Q9BY66/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene KDM5D","url":"https://civicdb.org/features/6556","note":"1 evidence items, 0 assertions, 1 variants; diseases: Prostate Cancer (GraphQL API, CC0)"}],"specificity":"broadly-expressed","distribution":"one-type","specificityNote":"Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA KDM5D: RNA low tissue specificity; no normal tissue stained high. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Prostate cancer); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"Human Protein Atlas KDM5D tissue","url":"https://www.proteinatlas.org/ENSG00000012817-KDM5D/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000012817 associations","url":"https://platform.opentargets.org/target/ENSG00000012817/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:11115","ensembl":"ENSG00000012817","uniprot":"Q9BY66","entrez":"8284","firstDescribed":1996,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Kent-First M.G. et al, Nat. Genet, 1996, \"Gene sequence and evolutionary conservation of human SMCY\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/8841177/","biology":"Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis. Involved in transcriptional repression of diverse metastasis-associated genes; in this function seems to cooperate with ZMYND8. Suppresses prostate cancer cell invasion. Location: Nucleus (UniProt). Locus Yq11.223 (HGNC).","whereFound":["Prostate cancer: CIViC evidence names this disease"],"targetClass":"transcription","prevalence":[]},"route":"/targets/kdm5d/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}]}}