{"entity":{"id":"kdm5c","kind":"target","name":"KDM5C","aka":["lysine demethylase 5C","Lysine-specific demethylase 5C","DXS1272E","XE169","JARID1C","MRX13"],"tldr":"KDM5C (Lysine-specific demethylase 5C) is a protein that switches other genes on and off. The public catalogues list it as a drug target, an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Renal cell carcinoma, Head and neck squamous cell carcinoma, Ovarian cancer and 5 more.","summary":"Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'.\n\nCIViC holds 2 clinical evidence items and 0 assertions across 2 variants, naming Everolimus, Capivasertib and Sunitinib. Open Targets scores its association with cancer at 0.74 (direct and indirect evidence; datatypes literature 0.98, animal model 0.44, genetic association 0.00, somatic mutation 0.96). IntOGen calls it a driver in 10 cohorts (1 activating, 9 loss-of-function), covering Renal Clear Cell Carcinoma, Head and Neck Squamous Cell Carcinoma, Lung Adenocarcinoma, Ovarian Epithelial Tumour, Pancreatic Adenocarcinoma, Plasma Cell Myeloma and others.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:11114","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11114"},{"label":"UniProt P41229","url":"https://www.uniprot.org/uniprotkb/P41229/entry"},{"label":"NCBI Gene 8242","url":"https://www.ncbi.nlm.nih.gov/gene/8242"},{"label":"Ensembl ENSG00000126012","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000126012"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets","intogen"],"cancers":["rcc","head-and-neck","ovarian","pancreatic","multiple-myeloma","skin-cancer","colorectal","clear-cell-rcc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 3 therapies; IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 9 cohorts; CIViC holds 2 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"KDM5C","role":["drug-target","oncogene-driver","tumour-suppressor","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:11114","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11114","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P41229","url":"https://www.uniprot.org/uniprotkb/P41229/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene KDM5C","url":"https://civicdb.org/features/6538","note":"2 evidence items, 0 assertions, 2 variants; diseases: Oestrogen Receptor-positive Breast Cancer, Renal Cell Carcinoma (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000126012","url":"https://platform.opentargets.org/target/ENSG00000126012/associations","note":"association with cancer (MONDO_0004992) 0.74; per-cancer scores at or above 0.5: colorectal cancer 0.53, renal cell carcinoma 0.68, skin cancer 0.54 (GraphQL API, CC0)"},{"label":"IntOGen KDM5C","url":"https://www.intogen.org/search?gene=KDM5C","note":"driver in 10 cohorts (Act 1, LoF 9); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"specificity":"tumour-specific","distribution":"many-types","specificityNote":"Tumour-specific alteration: the catalogues call it an oncogene driver (IntOGen cohort analysis finds it activated more often than chance) and a tumour suppressor (IntOGen finds it knocked out more often than chance), so the direction differs between cohorts but the alteration is somatic either way; what a medicine would aim at or exploit is the altered form or its loss, absent from normal cells; no corpus medicine is aimed at it yet. HPA KDM5C: RNA low tissue specificity; no normal tissue stained high. Distribution: 7 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Renal cell carcinoma, Head and neck squamous cell carcinoma, Ovarian cancer, Pancreatic ductal adenocarcinoma, Multiple myeloma, Skin cancer (all types), Colorectal cancer); Open Targets associates it with 1 specific cancer type at or above 0.5 (clear cell renal carcinoma). (Rule 6 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"UniProt P41229","url":"https://www.uniprot.org/uniprotkb/P41229/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene KDM5C","url":"https://civicdb.org/features/6538","note":"2 evidence items, 0 assertions, 2 variants; diseases: Oestrogen Receptor-positive Breast Cancer, Renal Cell Carcinoma (GraphQL API, CC0)"},{"label":"IntOGen KDM5C","url":"https://www.intogen.org/search?gene=KDM5C","note":"driver in 10 cohorts (Act 1, LoF 9); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"},{"label":"Human Protein Atlas KDM5C tissue","url":"https://www.proteinatlas.org/ENSG00000126012-KDM5C/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000126012 associations","url":"https://platform.opentargets.org/target/ENSG00000126012/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:11114","ensembl":"ENSG00000126012","uniprot":"P41229","entrez":"8242","firstDescribed":1994,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Wu et al, Hum. Mol. Genet, 1994, \"Isolation and characterization of XE169, a novel human gene that escapes X-inactivation\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/8162017/","biology":"Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2. Location: Nucleus (UniProt). Locus Xp11.22 (HGNC).","whereFound":["Renal cell carcinoma: Open Targets association 0.68 with renal cell carcinoma (MONDO_0005086); CIViC evidence names this disease","Head and neck squamous cell carcinoma: IntOGen driver in 1 cohort (HNSC)","Ovarian cancer: IntOGen driver in 1 cohort (OVT)","Pancreatic ductal adenocarcinoma: IntOGen driver in 1 cohort (PAAD)","Multiple myeloma: IntOGen driver in 1 cohort (PCM)","Skin cancer: Open Targets association 0.54 with skin cancer (MONDO_0002898)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/kdm5c/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"clear-cell-rcc","kind":"cancer","name":"Clear cell renal cell carcinoma","route":"/cancers/clear-cell-rcc/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"},{"id":"multiple-myeloma","kind":"cancer","name":"Multiple myeloma","route":"/cancers/multiple-myeloma/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"},{"id":"rcc","kind":"cancer","name":"Renal cell carcinoma","route":"/cancers/rcc/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}