{"entity":{"id":"kcnh7","kind":"target","name":"KCNH7","aka":["potassium voltage-gated channel subfamily H member 7","Voltage-gated inwardly rectifying potassium channel KCNH7","Kv11.3","HERG3","erg3"],"tldr":"KCNH7 (Voltage-gated inwardly rectifying potassium channel KCNH7) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.","summary":"Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Exhibits faster activation and deactivation kinetics and slow inactivation at membrane potentials positive to 240 mV, resulting in the weakest inward rectification.\n\nOpen Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.11, genetic association 0.27, clinical 0.76).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:18863","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18863"},{"label":"UniProt Q9NS40","url":"https://www.uniprot.org/uniprotkb/Q9NS40/entry"},{"label":"NCBI Gene 90134","url":"https://www.ncbi.nlm.nih.gov/gene/90134"},{"label":"Ensembl ENSG00000184611","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000184611"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.76. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"KCNH7","role":["drug-target"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:18863","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18863","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9NS40","url":"https://www.uniprot.org/uniprotkb/Q9NS40/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000184611","url":"https://platform.opentargets.org/target/ENSG00000184611/associations","note":"association with cancer (MONDO_0004992) 0.52;  (GraphQL API, CC0)"}],"distribution":"one-type","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA KCNH7: RNA tissue enhanced (brain 2 nTPM, retina 1 nTPM); no normal tissue stained high. Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 1 specific cancer type at or above 0.5 (Lambert-Eaton myasthenic syndrome). (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas KCNH7 tissue","url":"https://www.proteinatlas.org/ENSG00000184611-KCNH7/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000184611 associations","url":"https://platform.opentargets.org/target/ENSG00000184611/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:18863","ensembl":"ENSG00000184611","uniprot":"Q9NS40","entrez":"90134","firstDescribed":1997,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Ganetzky et al, 1997, \"Polynucleotides encoding herg-3 potassium channel\".","firstDescribedSource":"https://www.uniprot.org/uniprotkb/Q9NS40/entry","biology":"Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Exhibits faster activation and deactivation kinetics and slow inactivation at membrane potentials positive to 240 mV, resulting in the weakest inward rectification. Location: Cell membrane (UniProt). Locus 2q24.2 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/kcnh7/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}