{"entity":{"id":"katy-rezvani","kind":"person","name":"Katayoun Rezvani","aka":[],"tldr":"Created cord blood-derived CAR-NK cells, the first off-the-shelf CAR cell therapy to show remissions in lymphoma.","summary":"Katy Rezvani led the development and first-in-human trial of CD19-directed CAR natural killer cells derived from cord blood, which produced remissions in most patients with relapsed CLL and lymphoma without cytokine release syndrome or graft-versus-host disease, establishing NK cells as an allogeneic platform. Her laboratory engineers NK cells against solid tumour and myeloid targets and she directs the cell therapy programme at MD Anderson.","asOf":"2026-09-10","links":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Rezvani%20K%5BAuthor%5D%20CAR%20NK"}],"tags":["cell-therapy","nk-cells","off-the-shelf"],"related":[],"cancers":["cll","dlbcl"],"sections":[],"technologies":["car-nk-macrophage","allogeneic-cell-therapy"],"targets":["cd19"],"drugs":[],"companies":[],"institutions":["md-anderson"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["leukemia"],"dependsOn":[],"notes":[],"role":"Professor of Stem Cell Transplantation and Cellular Therapy, MD Anderson Cancer Center","institutionId":"md-anderson","specialisms":["CAR-NK cell therapy","Cord blood-derived cell therapy","Allogeneic immunotherapy","Transplant immunology"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Rezvani%20K%5BAuthor%5D%20CAR%20NK"}],"papers":[{"title":"Use of CAR-transduced natural killer cells in CD19-positive lymphoid tumors","journal":"NEJM","year":2020,"doi":"10.1056/NEJMoa1910607"},{"title":"Cord blood NK cells engineered to express IL-15 and a CD19-targeted CAR show long-term persistence and potent antitumor activity","journal":"Leukemia","year":2018,"doi":"10.1038/leu.2017.226"}]},"route":"/people/katy-rezvani/","neighbours":{"cancer":[{"id":"cll","kind":"cancer","name":"Chronic lymphocytic leukaemia","route":"/cancers/cll/"},{"id":"dlbcl","kind":"cancer","name":"Diffuse large B-cell lymphoma","route":"/cancers/dlbcl/"}],"technology":[{"id":"allogeneic-cell-therapy","kind":"technology","name":"Allogeneic (off-the-shelf) cell therapy","route":"/technologies/allogeneic-cell-therapy/"},{"id":"car-nk-macrophage","kind":"technology","name":"CAR-NK & CAR-macrophage","route":"/technologies/car-nk-macrophage/"}],"target":[{"id":"cd19","kind":"target","name":"CD19","route":"/targets/cd19/"}],"institution":[{"id":"md-anderson","kind":"institution","name":"MD Anderson Cancer Center","route":"/institutions/md-anderson/"}],"journal":[{"id":"leukemia","kind":"journal","name":"Leukemia","route":"/journals/leukemia/"}]}}