{"entity":{"id":"karmanos","kind":"institution","name":"Barbara Ann Karmanos Cancer Institute","aka":["Karmanos","Michigan Cancer Foundation"],"tldr":"Detroit's NCI comprehensive cancer centre, where the MCF-7 breast cancer cell line was derived in 1973, now part of McLaren Health Care.","summary":"Karmanos descends from the Michigan Cancer Foundation, where in 1973 Herbert Soule derived MCF-7, the oestrogen-receptor-positive breast cancer cell line that became the most studied cancer cell model in the world. NCI-designated since 1978, it is Wayne State University's cancer centre and, since 2014, part of McLaren Health Care, giving it a statewide network of cancer sites across Michigan. It has long run one of the larger academic phase 1 programmes and studies cancer in Detroit's predominantly Black population. Karmanos also operates the Detroit metropolitan SEER registry.","asOf":"2026-09-09","wikipedia":"https://en.wikipedia.org/wiki/Karmanos_Cancer_Institute","links":[{"label":"Karmanos Cancer Institute","url":"https://www.karmanos.org"}],"tags":[],"related":[],"cancers":["breast-hr-positive"],"sections":[],"technologies":["endocrine-therapy"],"targets":["estrogen-receptor"],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["real-world-evidence"],"trials":[],"people":["boris-pasche"],"bottlenecks":["b-preclinical-models","b-trial-diversity"],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"city":"Detroit, MI","country":"US","lat":42.354,"lng":-83.058,"institutionType":"cancer-center","website":"https://www.karmanos.org","nci":"comprehensive","university":"Wayne State University","programs":["Phase 1 trials","Breast cancer biology (MCF-7 heritage)","Population science (Detroit SEER)"]},"route":"/institutions/karmanos/","neighbours":{"cancer":[{"id":"breast-hr-positive","kind":"cancer","name":"HR-positive / HER2-negative breast cancer","route":"/cancers/breast-hr-positive/"}],"technology":[{"id":"endocrine-therapy","kind":"technology","name":"Endocrine therapy (SERMs, AIs, SERDs)","route":"/technologies/endocrine-therapy/"}],"target":[{"id":"estrogen-receptor","kind":"target","name":"Estrogen receptor (ERα)","route":"/targets/estrogen-receptor/"}],"term":[{"id":"real-world-evidence","kind":"term","name":"Real-world evidence","route":"/terms/real-world-evidence/"}],"person":[{"id":"boris-pasche","kind":"person","name":"Boris C. Pasche","route":"/people/boris-pasche/"}],"bottleneck":[{"id":"b-preclinical-models","kind":"bottleneck","name":"Lab models that fail to predict what happens in patients","route":"/bottlenecks/b-preclinical-models/"},{"id":"b-trial-diversity","kind":"bottleneck","name":"Trials do not represent the people who get cancer","route":"/bottlenecks/b-trial-diversity/"}],"institution":[{"id":"nci","kind":"institution","name":"National Cancer Institute (NIH)","route":"/institutions/nci/"}],"collection":[{"id":"nci-cancer-centers","kind":"collection","name":"NCI-Designated Cancer Centers","route":"/collections/nci-cancer-centers/"}]}}