{"entity":{"id":"joshua-brody","kind":"person","name":"Joshua Brody","aka":[],"tldr":"Developed in situ vaccination, turning a single injected lymphoma tumour into a vaccine against the rest.","summary":"Joshua Brody is Director of the Lymphoma Immunotherapy Program at The Mount Sinai Hospital and Tisch Cancer Institute. He is a haematologist-oncologist known for developing in situ vaccination, turning a single injected lymphoma tumour into a vaccine against the rest by combining Flt3L, radiation and a TLR agonist to induce systemic responses. His selected paper reports systemic clinical tumour regressions and potentiation of PD-1 blockade with in situ vaccination. He now leads bispecific antibody and CAR-T trials in diffuse large B-cell lymphoma.","asOf":"2026-09-08","links":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Brody%20JD%5BAuthor%5D"}],"tags":[],"related":[],"cancers":["dlbcl"],"sections":[],"technologies":["shared-antigen-vaccine","t-cell-engager"],"targets":[],"drugs":[],"companies":[],"institutions":["mount-sinai"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Director, Lymphoma Immunotherapy Program","institutionId":"mount-sinai","specialisms":["Lymphoma","In situ vaccination","Bispecific antibodies"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Brody%20JD%5BAuthor%5D"}],"papers":[{"title":"Systemic clinical tumor regressions and potentiation of PD1 blockade with in situ vaccination","journal":"Nature Medicine","year":2019,"url":"https://doi.org/10.1038/s41591-019-0410-x","doi":"10.1038/s41591-019-0410-x"}]},"route":"/people/joshua-brody/","neighbours":{"cancer":[{"id":"dlbcl","kind":"cancer","name":"Diffuse large B-cell lymphoma","route":"/cancers/dlbcl/"}],"technology":[{"id":"shared-antigen-vaccine","kind":"technology","name":"Off-the-shelf cancer vaccines","route":"/technologies/shared-antigen-vaccine/"},{"id":"t-cell-engager","kind":"technology","name":"T-cell engagers (bispecific)","route":"/technologies/t-cell-engager/"}],"institution":[{"id":"mount-sinai","kind":"institution","name":"The Mount Sinai Hospital / Tisch Cancer Institute","route":"/institutions/mount-sinai/"}]}}