{"entity":{"id":"joseph-sparano","kind":"person","name":"Joseph A. Sparano","aka":[],"tldr":"Led TAILORx, which showed most women with intermediate Oncotype scores can safely skip chemotherapy.","summary":"Joseph Sparano was study chair of TAILORx, the ECOG-ACRIN trial of 10,000 women that showed endocrine therapy alone is non-inferior to chemo-endocrine therapy for HR-positive, node-negative breast cancer with a mid-range 21-gene recurrence score. The result spared tens of thousands of patients chemotherapy each year and made genomic assays standard in early breast cancer. He continues to lead ECOG-ACRIN breast trials on treatment de-escalation and ctDNA.","asOf":"2026-09-10","links":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Sparano%20JA%5BAuthor%5D%20TAILORx"}],"tags":["breast","de-escalation","ecog-acrin"],"related":[],"cancers":["breast-hr-positive"],"sections":[],"technologies":["companion-diagnostic"],"targets":[],"drugs":["oncotype-dx"],"companies":[],"institutions":["mount-sinai"],"pathways":[],"terms":[],"trials":["tailorx"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Chief, Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai","institutionId":"mount-sinai","specialisms":["Early breast cancer","Genomic assays","Chemotherapy de-escalation","Cooperative-group trials"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Sparano%20JA%5BAuthor%5D%20TAILORx"}],"papers":[{"title":"Adjuvant chemotherapy guided by a 21-gene expression assay in breast cancer (TAILORx)","journal":"NEJM","year":2018,"doi":"10.1056/NEJMoa1804710"},{"title":"Clinical and genomic risk to guide the use of adjuvant therapy for breast cancer","journal":"NEJM","year":2019,"doi":"10.1056/NEJMoa1904819"}],"orcid":"0000-0002-9031-2010"},"route":"/people/joseph-sparano/","neighbours":{"cancer":[{"id":"breast-hr-positive","kind":"cancer","name":"HR-positive / HER2-negative breast cancer","route":"/cancers/breast-hr-positive/"}],"technology":[{"id":"companion-diagnostic","kind":"technology","name":"Companion diagnostics","route":"/technologies/companion-diagnostic/"}],"drug":[{"id":"oncotype-dx","kind":"drug","name":"Oncotype DX","route":"/drugs/oncotype-dx/"}],"institution":[{"id":"mount-sinai","kind":"institution","name":"The Mount Sinai Hospital / Tisch Cancer Institute","route":"/institutions/mount-sinai/"}],"trial":[{"id":"tailorx","kind":"trial","name":"TAILORx","route":"/trials/tailorx/"}]}}