{"entity":{"id":"johns-hopkins","kind":"institution","name":"Johns Hopkins Hospital / Sidney Kimmel Comprehensive Cancer Center","aka":[],"tldr":"Johns Hopkins is the birthplace of cancer genomics (Vogelstein), MSI-high immunotherapy (Le, Diaz), and liquid biopsy and MCED science (CancerSEEK).","summary":"Johns Hopkins Hospital and its Sidney Kimmel Comprehensive Cancer Center in Baltimore are where cancer genomics began with Vogelstein and Kinzler, and the centre holds NCI comprehensive designation and tenth place in the Newsweek/Statista oncology ranking. Its record includes pembrolizumab in mismatch-repair-deficient tumours, the first tumour-agnostic approval, led by Le and Diaz, the CancerSEEK liquid biopsy that fed Exact Sciences' multi-cancer early detection programme, and the Bloomberg-Kimmel Institute for Cancer Immunotherapy under Drew M. Pardoll and Elizabeth M. Jaffee. OnCo links it to DELFI Diagnostics, to the DETECT-A, DYNAMIC and CheckMate 816 papers, and to pathways from epigenetic reprogramming to telomere maintenance. Whether blood-based early detection lowers harm as well as finding cancers is the question its own work posed. Programmes and people are listed below.","asOf":"2026-09-04","links":[{"label":"Official website","url":"https://www.hopkinsmedicine.org/kimmel-cancer-center"},{"label":"PTCOG: particle therapy facilities in operation","url":"https://www.ptcog.site/index.php/facilities-in-operation-public"}],"tags":[],"related":["break-through-cancer"],"cancers":[],"sections":[],"technologies":["mced","liquid-biopsy","proton-therapy","proton-therapy-systems","gamma-knife","radiosurgery-srs"],"targets":[],"drugs":["pembrolizumab"],"companies":[],"institutions":[],"pathways":[],"terms":["msi"],"trials":[],"people":["william-nelson","elizabeth-jaffee","stephen-baylin","kellie-smith","nickolas-papadopoulos","bert-vogelstein","drew-pardoll","dung-le","julie-brahmer","kenneth-kinzler","patrick-forde","suzanne-topalian"],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"city":"Baltimore","country":"US","lat":39.297,"lng":-76.593,"institutionType":"cancer-center","website":"https://www.hopkinsmedicine.org/kimmel-cancer-center","nci":"comprehensive","newsweekOncology2026":10,"university":"Johns Hopkins University","programs":["Cancer genomics","MSI-H immunotherapy","Liquid biopsy / MCED","Bloomberg-Kimmel Immunotherapy"]},"route":"/institutions/johns-hopkins/","neighbours":{"company":[{"id":"break-through-cancer","kind":"company","name":"Break Through Cancer","route":"/companies/break-through-cancer/"},{"id":"delfi-diagnostics","kind":"company","name":"DELFI Diagnostics","route":"/companies/delfi-diagnostics/"},{"id":"hitachi","kind":"company","name":"Hitachi (particle therapy)","route":"/companies/hitachi/"}],"technology":[{"id":"gamma-knife","kind":"technology","name":"Gamma Knife","route":"/technologies/gamma-knife/"},{"id":"liquid-biopsy","kind":"technology","name":"Liquid biopsy (ctDNA)","route":"/technologies/liquid-biopsy/"},{"id":"mced","kind":"technology","name":"Multi-cancer early detection (MCED)","route":"/technologies/mced/"},{"id":"proton-therapy","kind":"technology","name":"Proton therapy","route":"/technologies/proton-therapy/"},{"id":"proton-therapy-systems","kind":"technology","name":"Proton therapy machines: cyclotrons, synchrotrons and single-room systems","route":"/technologies/proton-therapy-systems/"},{"id":"radiosurgery-srs","kind":"technology","name":"Stereotactic radiosurgery (Gamma Knife, CyberKnife, linac SRS)","route":"/technologies/radiosurgery-srs/"}],"drug":[{"id":"pembrolizumab","kind":"drug","name":"Pembrolizumab","route":"/drugs/pembrolizumab/"}],"term":[{"id":"bipolar-androgen-therapy","kind":"term","name":"Bipolar androgen therapy (BAT)","route":"/terms/bipolar-androgen-therapy/"},{"id":"caps-consortium-pancreatic-screening","kind":"term","name":"CAPS: the Cancer of the Pancreas Screening consortium and its surveillance studies (CAPS1 to CAPS5)","route":"/terms/caps-consortium-pancreatic-screening/"},{"id":"detect-a-study","kind":"term","name":"DETECT-A: a blood test plus PET-CT to screen 10,006 women with no symptoms","route":"/terms/detect-a-study/"},{"id":"msi","kind":"term","name":"Microsatellite instability (MSI-H) / mismatch repair deficiency (dMMR)","route":"/terms/msi/"}],"person":[{"id":"amanda-fader","kind":"person","name":"Amanda Nickles Fader","route":"/people/amanda-fader/"},{"id":"bert-vogelstein","kind":"person","name":"Bert Vogelstein","route":"/people/bert-vogelstein/"},{"id":"daniel-ludwig","kind":"person","name":"Daniel K. Ludwig","route":"/people/daniel-ludwig/"},{"id":"david-koch","kind":"person","name":"David H. Koch","route":"/people/david-koch/"},{"id":"drew-pardoll","kind":"person","name":"Drew M. Pardoll","route":"/people/drew-pardoll/"},{"id":"dung-le","kind":"person","name":"Dung T. Le","route":"/people/dung-le/"},{"id":"elizabeth-jaffee","kind":"person","name":"Elizabeth M. Jaffee","route":"/people/elizabeth-jaffee/"},{"id":"henrietta-lacks","kind":"person","name":"Henrietta Lacks","route":"/people/henrietta-lacks/"},{"id":"julie-brahmer","kind":"person","name":"Julie R. Brahmer","route":"/people/julie-brahmer/"},{"id":"kellie-smith","kind":"person","name":"Kellie N. Smith","route":"/people/kellie-smith/"},{"id":"kenneth-kinzler","kind":"person","name":"Kenneth W. Kinzler","route":"/people/kenneth-kinzler/"},{"id":"michael-bloomberg","kind":"person","name":"Michael Bloomberg","route":"/people/michael-bloomberg/"},{"id":"nickolas-papadopoulos","kind":"person","name":"Nickolas Papadopoulos","route":"/people/nickolas-papadopoulos/"},{"id":"patrick-forde","kind":"person","name":"Patrick M. Forde","route":"/people/patrick-forde/"},{"id":"sidney-kimmel","kind":"person","name":"Sidney Kimmel","route":"/people/sidney-kimmel/"},{"id":"stephen-baylin","kind":"person","name":"Stephen B. Baylin","route":"/people/stephen-baylin/"},{"id":"suzanne-topalian","kind":"person","name":"Suzanne L. Topalian","route":"/people/suzanne-topalian/"},{"id":"william-nelson","kind":"person","name":"William G. 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