{"entity":{"id":"john-maris","kind":"person","name":"John M. Maris","aka":[],"tldr":"Neuroblastoma geneticist whose lab found the ALK mutations and immunotherapy targets now in paediatric trials.","summary":"John Maris led the discovery that ALK mutations drive familial and sporadic neuroblastoma, the first targetable oncogene in the disease, and genome-wide association studies of neuroblastoma susceptibility. His laboratory identified GPC2 and other cell-surface targets for paediatric immunotherapy and he co-leads the NCI Pediatric Immunotherapy Discovery and Development Network.","asOf":"2026-09-10","wikipedia":"https://en.wikipedia.org/wiki/John_M._Maris","links":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Maris%20JM%5BAuthor%5D%20neuroblastoma"}],"tags":["paediatric","neuroblastoma","genomics"],"related":[],"cancers":["neuroblastoma"],"sections":[],"technologies":["wes-wgs"],"targets":["alk"],"drugs":[],"companies":[],"institutions":["chop"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Giulio D'Angio Chair in Neuroblastoma Research, Children's Hospital of Philadelphia","institutionId":"chop","specialisms":["Neuroblastoma genomics","Paediatric oncology","Immunotherapy targets","Precision medicine"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Maris%20JM%5BAuthor%5D%20neuroblastoma"}],"papers":[{"title":"Identification of ALK as a major familial neuroblastoma predisposition gene","journal":"Nature","year":2008,"doi":"10.1038/nature07261"},{"title":"Recent advances in neuroblastoma","journal":"NEJM","year":2010,"doi":"10.1056/NEJMra0804577"}]},"route":"/people/john-maris/","neighbours":{"cancer":[{"id":"neuroblastoma","kind":"cancer","name":"Neuroblastoma (paediatric)","route":"/cancers/neuroblastoma/"}],"technology":[{"id":"wes-wgs","kind":"technology","name":"Whole-exome & whole-genome sequencing","route":"/technologies/wes-wgs/"}],"target":[{"id":"alk","kind":"target","name":"ALK","route":"/targets/alk/"}],"institution":[{"id":"chop","kind":"institution","name":"Children's Hospital of Philadelphia","route":"/institutions/chop/"}]}}