{"entity":{"id":"jeffrey-dome","kind":"person","name":"Jeffrey S. Dome","aka":[],"tldr":"Led the COG renal tumour committee that used biology to tailor Wilms tumour treatment.","summary":"Jeffrey Dome (Children's National Hospital) chaired the Children's Oncology Group renal tumour committee and led the AREN trials that incorporated loss of heterozygosity at 1p and 16q and lung nodule response into risk-adapted Wilms tumour therapy, allowing many children to avoid lung radiotherapy or doxorubicin. His laboratory studies telomerase and relapse biology in Wilms tumour.","asOf":"2026-09-10","links":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Dome%20JS%5BAuthor%5D%20Wilms"}],"tags":["paediatric","wilms-tumor","cooperative-group"],"related":[],"cancers":["wilms-tumor"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":["childrens-national-hospital"],"pathways":[],"terms":["radiotherapy","de-escalation"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Senior Vice President, Center for Cancer and Blood Disorders, Children's National Hospital, Washington DC","institutionId":"childrens-national-hospital","specialisms":["Wilms tumour","Paediatric renal tumours","Risk-adapted therapy","Cooperative-group trials"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Dome%20JS%5BAuthor%5D%20Wilms"}],"papers":[{"title":"Advances in Wilms tumor treatment and biology: progress through international collaboration","journal":"JCO","year":2015,"doi":"10.1200/JCO.2015.62.1888"},{"title":"Treatment of stage IV favorable histology Wilms tumor with lung metastases: a report from the Children's Oncology Group AREN0533 study","journal":"JCO","year":2018,"doi":"10.1200/JCO.2017.77.1931"}]},"route":"/people/jeffrey-dome/","neighbours":{"cancer":[{"id":"wilms-tumor","kind":"cancer","name":"Wilms tumour (nephroblastoma)","route":"/cancers/wilms-tumor/"}],"institution":[{"id":"childrens-national-hospital","kind":"institution","name":"Children's National Hospital","route":"/institutions/childrens-national-hospital/"}],"term":[{"id":"de-escalation","kind":"term","name":"De-escalation, escalation and response-adapted therapy","route":"/terms/de-escalation/"},{"id":"radiotherapy","kind":"term","name":"Radiotherapy","route":"/terms/radiotherapy/"}]}}