{"entity":{"id":"jeffrey-bradley","kind":"person","name":"Jeffrey D. Bradley","aka":[],"tldr":"Led RTOG 0617, the trial that showed higher radiation doses do not help in stage III lung cancer and set today's 60 Gy standard.","summary":"Jeffrey Bradley was principal investigator of RTOG 0617, which unexpectedly found that escalating the dose to 74 Gy worsened survival compared with 60 Gy in stage III NSCLC, a result that fixed the standard dose and refocused the field on precision and cardiac sparing. He led the NRG proton-versus-photon lung trial and chairs thoracic radiotherapy committees in NRG Oncology.","asOf":"2026-09-10","links":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Bradley%20JD%5BAuthor%5D%20RTOG%200617"}],"tags":["radiotherapy","lung","nrg-oncology"],"related":[],"cancers":["nsclc"],"sections":[],"technologies":["imrt-igrt","proton-therapy"],"targets":[],"drugs":[],"companies":[],"institutions":["penn-abramson"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Professor and Vice Chair of Radiation Oncology, University of Pennsylvania Perelman School of Medicine","institutionId":"penn-abramson","specialisms":["Thoracic radiation oncology","Dose escalation","Proton therapy","Cooperative-group trials"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Bradley%20JD%5BAuthor%5D%20RTOG%200617"}],"papers":[{"title":"Standard-dose versus high-dose conformal radiotherapy with concurrent and consolidation carboplatin plus paclitaxel with or without cetuximab for patients with stage IIIA or IIIB non-small-cell lung cancer (RTOG 0617)","journal":"Lancet Oncology","year":2015,"doi":"10.1016/S1470-2045(14)71207-0"},{"title":"Long-term results of NRG Oncology RTOG 0617","journal":"JCO","year":2020,"doi":"10.1200/JCO.19.01162"}]},"route":"/people/jeffrey-bradley/","neighbours":{"cancer":[{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"}],"technology":[{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"},{"id":"proton-therapy","kind":"technology","name":"Proton therapy","route":"/technologies/proton-therapy/"}],"institution":[{"id":"penn-abramson","kind":"institution","name":"Abramson Cancer Center, University of Pennsylvania","route":"/institutions/penn-abramson/"}],"trial":[{"id":"pacific-2","kind":"trial","name":"PACIFIC-2","route":"/trials/pacific-2/"}]}}