{"entity":{"id":"jefferson-kimmel","kind":"institution","name":"Sidney Kimmel Comprehensive Cancer Center at Jefferson Health","aka":["SKCC Jefferson"],"tldr":"Thomas Jefferson University's NCI-designated cancer centre, known for prostate cancer biology and GUCY2C-targeted colorectal cancer immunotherapy.","summary":"NCI-designated since 1996, the Sidney Kimmel Comprehensive Cancer Center serves Philadelphia and southern New Jersey through Jefferson Health's hospital network. Scott Waldman identified guanylyl cyclase C (GUCY2C) as a colorectal cancer antigen and has carried vaccines and CAR-T against it into trials. Karen Knudsen, former director and later CEO of the American Cancer Society, built its androgen receptor and prostate cancer programme with urologist Leonard Gomella; Adam Dicker leads radiation oncology. The centre is a member of the NCI's cooperative group network and runs a community outreach programme across its catchment.","asOf":"2026-09-09","links":[{"label":"Sidney Kimmel Comprehensive Cancer Center","url":"https://www.jeffersonhealth.org/clinical-specialties/cancer"}],"tags":[],"related":[],"cancers":["prostate","colorectal"],"sections":["radiation","immunotherapy"],"technologies":["shared-antigen-vaccine","car-t"],"targets":["androgen-receptor"],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":["marcia-brose"],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"city":"Philadelphia, PA","country":"US","lat":39.949,"lng":-75.157,"institutionType":"cancer-center","website":"https://www.jeffersonhealth.org/clinical-specialties/cancer","nci":"comprehensive","university":"Thomas Jefferson University","programs":["Prostate cancer and AR biology","GUCY2C immunotherapy","Radiation oncology"]},"route":"/institutions/jefferson-kimmel/","neighbours":{"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}],"section":[{"id":"immunotherapy","kind":"section","name":"Immunotherapy","route":"/fronts/immunotherapy/"},{"id":"radiation","kind":"section","name":"Radiation Therapy","route":"/fronts/radiation/"}],"technology":[{"id":"car-t","kind":"technology","name":"CAR-T cell therapy","route":"/technologies/car-t/"},{"id":"shared-antigen-vaccine","kind":"technology","name":"Off-the-shelf cancer vaccines","route":"/technologies/shared-antigen-vaccine/"}],"target":[{"id":"androgen-receptor","kind":"target","name":"Androgen receptor","route":"/targets/androgen-receptor/"}],"person":[{"id":"marcia-brose","kind":"person","name":"Marcia S. Brose","route":"/people/marcia-brose/"},{"id":"sidney-kimmel","kind":"person","name":"Sidney Kimmel","route":"/people/sidney-kimmel/"}],"institution":[{"id":"nci","kind":"institution","name":"National Cancer Institute (NIH)","route":"/institutions/nci/"}]}}