{"entity":{"id":"jan-van-lanschot","kind":"person","name":"J. Jan B. van Lanschot","aka":[],"tldr":"Surgeon who led the CROSS trial, which made chemoradiotherapy before surgery the standard for oesophageal cancer.","summary":"Jan van Lanschot led the Dutch CROSS trial showing neoadjuvant carboplatin, paclitaxel and radiotherapy followed by surgery nearly doubles median survival compared with surgery alone in oesophageal and junctional cancer, a regimen adopted worldwide. He then led the SANO trial of active surveillance after complete clinical response, opening organ preservation in oesophageal cancer.","asOf":"2026-09-10","links":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=van%20Lanschot%20JJB%5BAuthor%5D%20esophageal%20CROSS"}],"tags":["esophageal","surgery","chemoradiotherapy"],"related":[],"cancers":["esophageal"],"sections":[],"technologies":[],"targets":[],"drugs":["carboplatin","paclitaxel"],"companies":[],"institutions":["erasmus-mc"],"pathways":[],"terms":[],"trials":["cross","sano"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Emeritus Professor of Surgery, Erasmus MC","institutionId":"erasmus-mc","specialisms":["Oesophageal surgery","Neoadjuvant chemoradiotherapy","Organ preservation"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=van%20Lanschot%20JJB%5BAuthor%5D%20esophageal%20CROSS"}],"papers":[{"title":"Preoperative chemoradiotherapy for esophageal or junctional cancer (CROSS)","journal":"NEJM","year":2012,"doi":"10.1056/NEJMoa1112088"},{"title":"Neoadjuvant chemoradiotherapy plus surgery versus surgery alone for oesophageal or junctional cancer (CROSS): long-term results of a randomised controlled trial","journal":"Lancet Oncology","year":2015,"doi":"10.1016/S1470-2045(15)00040-6"}]},"route":"/people/jan-van-lanschot/","neighbours":{"cancer":[{"id":"esophageal","kind":"cancer","name":"Oesophageal cancer","route":"/cancers/esophageal/"}],"drug":[{"id":"carboplatin","kind":"drug","name":"Carboplatin","route":"/drugs/carboplatin/"},{"id":"paclitaxel","kind":"drug","name":"Paclitaxel / nab-paclitaxel","route":"/drugs/paclitaxel/"}],"institution":[{"id":"erasmus-mc","kind":"institution","name":"Erasmus MC Cancer Institute","route":"/institutions/erasmus-mc/"}],"trial":[{"id":"cross","kind":"trial","name":"CROSS","route":"/trials/cross/"},{"id":"sano","kind":"trial","name":"SANO","route":"/trials/sano/"}]}}