{"entity":{"id":"james-yao","kind":"person","name":"James C. Yao","aka":[],"tldr":"Led the RADIANT trials that made everolimus a standard therapy for pancreatic and other neuroendocrine tumours.","summary":"James Yao was principal investigator of RADIANT-3 and RADIANT-4, which established everolimus for progressive pancreatic and then non-functional lung and GI neuroendocrine tumours, and authored the SEER analysis that documented the rising incidence of NETs. He chairs GI medical oncology at MD Anderson and co-led the NET Task Force of the NCI GI steering committee.","asOf":"2026-09-10","links":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Yao%20JC%5BAuthor%5D%20neuroendocrine%20everolimus"}],"tags":["neuroendocrine","mtor","trialist"],"related":[],"cancers":["neuroendocrine"],"sections":[],"technologies":["kinase-inhibitors"],"targets":[],"drugs":[],"companies":[],"institutions":["md-anderson"],"pathways":[],"terms":[],"trials":["radiant-3-4"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Chair, Department of Gastrointestinal Medical Oncology, MD Anderson Cancer Center","institutionId":"md-anderson","specialisms":["Neuroendocrine tumours","mTOR inhibitors","Epidemiology","Gastrointestinal oncology"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Yao%20JC%5BAuthor%5D%20neuroendocrine%20everolimus"}],"papers":[{"title":"Everolimus for advanced pancreatic neuroendocrine tumors (RADIANT-3)","journal":"NEJM","year":2011,"doi":"10.1056/NEJMoa1009290"},{"title":"Everolimus for the treatment of advanced, non-functional neuroendocrine tumours of the lung or gastrointestinal tract (RADIANT-4)","journal":"Lancet","year":2016,"doi":"10.1016/S0140-6736(15)00817-X"},{"title":"One hundred years after 'carcinoid': epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States","journal":"JCO","year":2008,"doi":"10.1200/JCO.2007.15.4377"}],"orcid":"0000-0002-1875-3962"},"route":"/people/james-yao/","neighbours":{"cancer":[{"id":"neuroendocrine","kind":"cancer","name":"Neuroendocrine tumours","route":"/cancers/neuroendocrine/"}],"technology":[{"id":"kinase-inhibitors","kind":"technology","name":"Small-molecule kinase inhibitors","route":"/technologies/kinase-inhibitors/"}],"institution":[{"id":"md-anderson","kind":"institution","name":"MD Anderson Cancer Center","route":"/institutions/md-anderson/"}],"trial":[{"id":"radiant-3-4","kind":"trial","name":"RADIANT-3 and RADIANT-4","route":"/trials/radiant-3-4/"}]}}