{"entity":{"id":"james-gulley","kind":"person","name":"James L. Gulley","aka":[],"tldr":"Runs NCI's immuno-oncology clinical programme, from prostate cancer vaccines to bifunctional checkpoint fusion proteins.","summary":"James L. Gulley is Co-Director of the Center for Immuno-Oncology in the Center for Cancer Research at the National Cancer Institute. He is a medical oncologist who runs NCI's immuno-oncology clinical programme, from prostate cancer vaccines to bifunctional checkpoint fusion proteins, having led the PROSTVAC programme and early studies of bintrafusp alfa. His selected paper reports the phase 3 trial of PROSTVAC in asymptomatic or minimally symptomatic metastatic castration-resistant prostate cancer. He coordinates immuno-oncology trials across NCI's intramural programme in prostate, bladder and other genitourinary cancers.","asOf":"2026-09-08","wikipedia":"https://en.wikipedia.org/wiki/James_L._Gulley","links":[{"label":"NCI CCR profile","url":"https://ccr.cancer.gov/staff-directory/james-l-gulley"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Gulley%20JL%5BAuthor%5D"}],"tags":[],"related":[],"cancers":["prostate","urothelial"],"sections":[],"technologies":["shared-antigen-vaccine","checkpoint-inhibitor"],"targets":[],"drugs":[],"companies":[],"institutions":["nci"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Co-Director, Center for Immuno-Oncology, Center for Cancer Research","institutionId":"nci","specialisms":["Genitourinary cancers","Cancer vaccines","Bifunctional immunotherapies"],"profiles":[{"label":"NCI CCR profile","url":"https://ccr.cancer.gov/staff-directory/james-l-gulley"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Gulley%20JL%5BAuthor%5D"}],"papers":[{"title":"Phase III trial of PROSTVAC in asymptomatic or minimally symptomatic metastatic castration-resistant prostate cancer","journal":"Journal of Clinical Oncology","year":2019}]},"route":"/people/james-gulley/","neighbours":{"cancer":[{"id":"urothelial","kind":"cancer","name":"Bladder & urothelial cancer","route":"/cancers/urothelial/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}],"technology":[{"id":"checkpoint-inhibitor","kind":"technology","name":"Immune checkpoint inhibitors","route":"/technologies/checkpoint-inhibitor/"},{"id":"shared-antigen-vaccine","kind":"technology","name":"Off-the-shelf cancer vaccines","route":"/technologies/shared-antigen-vaccine/"}],"institution":[{"id":"nci","kind":"institution","name":"National Cancer Institute (NIH)","route":"/institutions/nci/"},{"id":"nci-ccr","kind":"institution","name":"NCI Center for Cancer Research (intramural programme)","route":"/institutions/nci-ccr/"}]}}