{"entity":{"id":"jakob-nikolas-kather","kind":"person","name":"Jakob Nikolas Kather","aka":[],"tldr":"Showed that deep learning can read genetic features like microsatellite instability directly from routine pathology slides.","summary":"Jakob Nikolas Kather led the 2019 Nature Medicine study showing a deep-learning model can predict microsatellite instability from standard H&E slides in gastrointestinal cancer, opening the field of inferring molecular biomarkers from routine histology, and subsequent pan-cancer work predicting mutations and outcomes. He leads clinical AI research in Dresden, evaluates large language models for oncology, and is a practising GI oncologist.","asOf":"2026-09-10","links":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Kather%20JN%5BAuthor%5D%20deep%20learning%20histology"}],"tags":["ai","pathology","biomarkers","germany"],"related":[],"cancers":["colorectal","gastric"],"sections":[],"technologies":["digital-pathology-ai","pathology-foundation-model"],"targets":[],"drugs":[],"companies":[],"institutions":["nct-dresden"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["nature-cancer"],"dependsOn":[],"notes":[],"role":"Professor of Clinical Artificial Intelligence, Else Kröner Fresenius Center for Digital Health, TU Dresden; Medical Oncologist, NCT Dresden","institutionId":"nct-dresden","specialisms":["AI in oncology","Deep learning on histology","Biomarker prediction from slides","Large language models in medicine"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Kather%20JN%5BAuthor%5D%20deep%20learning%20histology"}],"papers":[{"title":"Deep learning can predict microsatellite instability directly from histology in gastrointestinal cancer","journal":"Nature Medicine","year":2019,"doi":"10.1038/s41591-019-0462-y"},{"title":"Pan-cancer image-based detection of clinically actionable genetic alterations","journal":"Nature Cancer","year":2020,"doi":"10.1038/s43018-020-0087-6"}],"orcid":"0000-0002-3730-5348"},"route":"/people/jakob-nikolas-kather/","neighbours":{"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"}],"technology":[{"id":"digital-pathology-ai","kind":"technology","name":"Digital pathology & AI","route":"/technologies/digital-pathology-ai/"},{"id":"pathology-foundation-model","kind":"technology","name":"Pathology & radiology foundation models","route":"/technologies/pathology-foundation-model/"}],"institution":[{"id":"nct-dresden","kind":"institution","name":"NCT/UCC Dresden, University Hospital Carl Gustav Carus","route":"/institutions/nct-dresden/"}],"journal":[{"id":"nature-cancer","kind":"journal","name":"Nature Cancer","route":"/journals/nature-cancer/"}]}}