{"entity":{"id":"jackson-laboratory","kind":"institution","name":"The Jackson Laboratory Cancer Center","aka":["JAX"],"tldr":"The Jackson Laboratory in Maine breeds the world's genetically defined laboratory mice, including the immunodeficient NSG strain behind patient-derived xenograft research, and has held NCI basic cancer centre status since 1983; its PDX repository is open to academic and industry researchers.","summary":"Founded in 1929 by Clarence Cook Little, The Jackson Laboratory is the world's principal source of genetically defined laboratory mice, including the immunodeficient NSG strain that underpins patient-derived xenograft research, and has held NCI basic laboratory designation since 1983. Its cancer centre studies cancer genetics and genomics, the tumour microenvironment and drug response using mouse and PDX resources, with a large PDX repository available to academic and industry researchers. JAX Genomic Medicine in Farmington, Connecticut, extends the institute into human genomics and computational biology, and the Mouse Genome Informatics database is a core community resource.","asOf":"2026-09-09","links":[{"label":"The Jackson Laboratory","url":"https://www.jax.org"}],"tags":[],"related":[],"cancers":[],"sections":["drug-discovery"],"technologies":["pdx-models","wes-wgs","crispr-screens"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":["karolina-palucka"],"bottlenecks":["b-preclinical-models","b-reproducibility"],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"city":"Bar Harbor, ME","country":"US","lat":44.388,"lng":-68.204,"institutionType":"research-institute","website":"https://www.jax.org","nci":"basic","programs":["Mouse models and PDX resource","Cancer genetics and genomics","Mouse Genome Informatics"]},"route":"/institutions/jackson-laboratory/","neighbours":{"section":[{"id":"drug-discovery","kind":"section","name":"Drug Discovery Platforms","route":"/fronts/drug-discovery/"}],"technology":[{"id":"crispr-screens","kind":"technology","name":"CRISPR functional genomics","route":"/technologies/crispr-screens/"},{"id":"pdx-models","kind":"technology","name":"Patient-derived xenografts","route":"/technologies/pdx-models/"},{"id":"wes-wgs","kind":"technology","name":"Whole-exome & whole-genome sequencing","route":"/technologies/wes-wgs/"}],"person":[{"id":"karolina-palucka","kind":"person","name":"Karolina Palucka","route":"/people/karolina-palucka/"}],"bottleneck":[{"id":"b-preclinical-models","kind":"bottleneck","name":"Lab models that fail to predict what happens in patients","route":"/bottlenecks/b-preclinical-models/"},{"id":"b-reproducibility","kind":"bottleneck","name":"Preclinical results do not reproduce","route":"/bottlenecks/b-reproducibility/"}],"institution":[{"id":"nci","kind":"institution","name":"National Cancer Institute (NIH)","route":"/institutions/nci/"}],"collection":[{"id":"nci-cancer-centers","kind":"collection","name":"NCI-Designated Cancer Centers","route":"/collections/nci-cancer-centers/"}]}}