{"entity":{"id":"j-silvio-gutkind","kind":"person","name":"J. Silvio Gutkind","aka":[],"tldr":"Cancer pharmacologist at UC San Diego known for work on G-protein signalling and mTOR-targeted therapy in head and neck cancer.","summary":"J. Silvio Gutkind, PhD, is Associate Director for Basic Science at UC San Diego Moores Cancer Center and Chair of the Department of Pharmacology. His laboratory studies G-protein-coupled receptor and PI3K/mTOR signalling in cancer, translating these findings into clinical trials of mTOR inhibitors and immunotherapy combinations in head and neck squamous cell carcinoma.","asOf":"2026-09-10","links":[{"label":"Institution profile","url":"https://moorescancercenter.ucsd.edu/about/leadership/"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Gutkind+JS%5BAuthor%5D"}],"tags":["clinician-scientist","head and neck cancer","signalling"],"related":[],"cancers":["head-and-neck"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":["ucsd-moores"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":["oncogene-journal"],"dependsOn":[],"notes":[],"role":"Associate Director, Basic Science; Professor and Chair, Department of Pharmacology","institutionId":"ucsd-moores","specialisms":["Head and neck cancer","Signal transduction","Cancer pharmacology"],"profiles":[{"label":"Institution profile","url":"https://moorescancercenter.ucsd.edu/about/leadership/"},{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Gutkind+JS%5BAuthor%5D"}],"papers":[{"title":"Inactivating mutations in GNA13 and RHOA in Burkitt’s lymphoma and diffuse large B-cell lymphoma: a tumor suppressor function for the Gα13/RhoA axis in B cells","journal":"Oncogene","year":2015,"doi":"10.1038/onc.2015.442"},{"title":"Monomethyl auristatin antibody and peptide drug conjugates for trimodal cancer chemo-radio-immunotherapy","journal":"Nature Communications","year":2022,"doi":"10.1038/s41467-022-31601-z"},{"title":"Redirecting extracellular proteases to molecularly guide radiosensitizing drugs to tumors","journal":"Biomaterials","year":2020,"doi":"10.1016/j.biomaterials.2020.120032"}]},"route":"/people/j-silvio-gutkind/","neighbours":{"cancer":[{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"}],"institution":[{"id":"ucsd-moores","kind":"institution","name":"UC San Diego Moores Cancer Center","route":"/institutions/ucsd-moores/"}],"journal":[{"id":"oncogene-journal","kind":"journal","name":"Oncogene","route":"/journals/oncogene-journal/"}]}}