{"entity":{"id":"isabl","kind":"company","name":"Isabl","aka":[],"tldr":"Isabl reads a tumour's whole genome and transcriptome instead of a small gene panel, and its software turns that into a report clinicians can use.","summary":"Isabl, a Memorial Sloan Kettering spin-out, provides software and a CLIA laboratory for clinical whole-genome and whole-transcriptome sequencing of tumours, analysing the full range of mutations, structural variants, signatures and expression rather than a targeted panel, with applications in treatment planning, disease surveillance and biomarker discovery. It states it is the first to receive New York State approval for a whole-genome and transcriptome cancer test. Evidence of clinical utility beyond analytical validation is still accumulating.","asOf":"2026-09-10","links":[{"label":"Y Combinator profile","url":"https://www.ycombinator.com/companies/isabl"},{"label":"Official website","url":"https://isabl.io"}],"tags":["yc"],"related":[],"cancers":[],"sections":["diagnostics"],"technologies":["wes-wgs","rna-seq","mrd-testing"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"hq":"New York, NY","country":"US","companyType":"diagnostics","website":"https://isabl.io","stage":"startup","ycBatch":"W20","investors":["y-combinator"],"funding":[]},"route":"/companies/isabl/","neighbours":{"section":[{"id":"diagnostics","kind":"section","name":"Diagnostics & Biomarkers","route":"/fronts/diagnostics/"}],"technology":[{"id":"mrd-testing","kind":"technology","name":"MRD / molecular residual disease testing","route":"/technologies/mrd-testing/"},{"id":"rna-seq","kind":"technology","name":"RNA sequencing & expression profiling","route":"/technologies/rna-seq/"},{"id":"wes-wgs","kind":"technology","name":"Whole-exome & whole-genome sequencing","route":"/technologies/wes-wgs/"}],"company":[{"id":"y-combinator","kind":"company","name":"Y Combinator","route":"/companies/y-combinator/"}]}}