{"entity":{"id":"invincible-3","kind":"trial","name":"A Study to Investigate Efficacy & Safety of Intratumoral INT230-6 Compared to US Standard of Care in Adults With Soft Tissue Sarcomas (INVINCIBLE-3)","aka":["INVINCIBLE-3"],"tldr":"A phase 3 trial testing INT230-6 in sarcomas, now recruiting.","summary":"A Study to Investigate Efficacy & Safety of Intratumoral INT230-6 Compared to US Standard of Care in Adults With Soft Tissue Sarcomas (INVINCIBLE-3) is a phase 3 interventional study registered as NCT06263231, led by Intensity Therapeutics with Premier Research, and recruiting on the registry. Official title: A Multicenter, Randomised, Phase 3 Study to Assess the Efficacy and Safety of INtratumorally Administered INT230-6 (SHAO, VINblastine, CIsplatin) Compared With US Standard of Care in Adults With Locally Recurrent, InoperaBLE, or Metastatic Soft Tissue Sarcomas (INVINCIBLE-3). Planned enrolment is 333 participants (estimated). The study started in 2024-06-28 and primary completion is expected in 2027-12. No results have been posted on ClinicalTrials.gov.","status":"recruiting","asOf":"2026-09-11","links":[{"label":"ClinicalTrials.gov NCT06263231","url":"https://clinicaltrials.gov/study/NCT06263231"}],"tags":["ctgov-ingest"],"related":[],"cancers":["sarcoma"],"sections":[],"technologies":[],"targets":[],"drugs":["int230-6"],"companies":["intensity-therapeutics"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT06263231","phase":"3","setting":"A Multicenter, Randomized, Phase 3 Study to Assess the Efficacy and Safety of INtratumorally Administered INT230-6 (SHAO, VINblastine, CIsplatin) Compared With US Standard of Care in Adults With Locally Recurrent, InoperaBLE, or Metastatic Soft Tissue Sarcomas (INVINCIBLE-3)","sponsor":"Intensity Therapeutics","started":"2024-06-28","startedType":"actual","enrolled":333,"enrolledBasis":"registry","outcomes":[]},"route":"/trials/invincible-3/","neighbours":{"cancer":[{"id":"sarcoma","kind":"cancer","name":"Sarcomas (soft tissue, bone, GIST)","route":"/cancers/sarcoma/"}],"drug":[{"id":"int230-6","kind":"drug","name":"INT230-6","route":"/drugs/int230-6/"}],"company":[{"id":"intensity-therapeutics","kind":"company","name":"Intensity Therapeutics","route":"/companies/intensity-therapeutics/"}]}}