{"entity":{"id":"institute-for-protein-design","kind":"institution","name":"Institute for Protein Design (University of Washington)","aka":[],"tldr":"David Baker's institute, where de novo protein design and the RFdiffusion models come from (Nobel Prize in Chemistry 2024).","summary":"The Institute for Protein Design at the University of Washington in Seattle is David Baker's institute, the origin of de novo protein design and the RFdiffusion models, work recognised by the Nobel Prize in Chemistry in 2024. It produced Rosetta, ProteinMPNN, RFdiffusion and RFdiffusion2, and the de novo binder design methods now used to make cancer-targeting proteins and antibodies from scratch, and its spin-outs include Xaira Therapeutics and Monod. OnCo connects it to the RFdiffusion and ProteinMPNN technology record and to Xaira. Whether designed binders reach the clinic faster and more safely than conventional antibodies is the question its spin-outs will answer. Its RFdiffusion, ProteinMPNN and de novo binder programmes are listed below.","asOf":"2026-09-08","links":[{"label":"Official website","url":"https://www.ipd.uw.edu"}],"tags":["ai","protein-design"],"related":[],"cancers":[],"sections":["drug-discovery","ai-computation"],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":["david-baker"],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"city":"Seattle","country":"US","lat":47.65,"lng":-122.308,"institutionType":"research-institute","website":"https://www.ipd.uw.edu","university":"University of Washington","programs":["RFdiffusion","ProteinMPNN","De novo binders"]},"route":"/institutions/institute-for-protein-design/","neighbours":{"section":[{"id":"ai-computation","kind":"section","name":"AI & Computation","route":"/fronts/ai-computation/"},{"id":"drug-discovery","kind":"section","name":"Drug Discovery Platforms","route":"/fronts/drug-discovery/"}],"person":[{"id":"david-baker","kind":"person","name":"David Baker","route":"/people/david-baker/"}],"company":[{"id":"xaira-therapeutics","kind":"company","name":"Xaira Therapeutics","route":"/companies/xaira-therapeutics/"}],"technology":[{"id":"rfdiffusion","kind":"technology","name":"RFdiffusion / RFdiffusion2 and ProteinMPNN (Baker Lab)","route":"/technologies/rfdiffusion/"}]}}