{"entity":{"id":"immunome","kind":"company","name":"Immunome","aka":["Immunome, Inc.","Ayala Pharmaceuticals"],"tldr":"Immunome is a US biotechnology company whose lead drug varegacestat, a gamma-secretase inhibitor acquired with Ayala Pharmaceuticals, completed the phase 3 RINGSIDE trial in progressing desmoid tumours; it also develops antibody-drug conjugates.","summary":"Immunome, headquartered in Bothell, Washington, develops targeted cancer therapies. Its most advanced programme is varegacestat (AL102), an oral gamma-secretase inhibitor that blocks Notch signalling and was tested against placebo in the phase 3 RINGSIDE trial in adults and adolescents with progressing desmoid tumours; the programme came with the acquisition of Ayala Pharmaceuticals' assets. The company also develops antibody-drug conjugates from its own antibody discovery platform. Sponsor and trial facts are from the ClinicalTrials.gov registry; company facts are from the official website.","asOf":"2026-09-11","links":[{"label":"Official website","url":"https://immunome.com/"},{"label":"ClinicalTrials.gov: trials led by Immunome","url":"https://clinicaltrials.gov/search?lead=Immunome"}],"tags":["ctgov-sponsor"],"related":[],"cancers":["desmoid-tumour"],"sections":["targeted-therapy"],"technologies":[],"targets":["gamma-secretase"],"drugs":["varegacestat"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":["nct04871282"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo ingestion (ClinicalTrials.gov v2 + sponsor websites)","editedOn":"2026-09-11"},"hq":"Bothell, WA","country":"US","companyType":"biotech","website":"https://immunome.com/","stage":"public","investors":[],"funding":[]},"route":"/companies/immunome/","neighbours":{"cancer":[{"id":"desmoid-tumour","kind":"cancer","name":"Desmoid tumour","route":"/cancers/desmoid-tumour/"}],"section":[{"id":"targeted-therapy","kind":"section","name":"Targeted Therapy","route":"/fronts/targeted-therapy/"}],"target":[{"id":"gamma-secretase","kind":"target","name":"Gamma-secretase (PSEN1)","route":"/targets/gamma-secretase/"}],"drug":[{"id":"varegacestat","kind":"drug","name":"Varegacestat","route":"/drugs/varegacestat/"}],"trial":[{"id":"nct04871282","kind":"trial","name":"A Study of AL102 in Patients With Progressing Desmoid Tumors","route":"/trials/nct04871282/"}]}}