{"entity":{"id":"il7r","kind":"target","name":"IL7R","aka":["interleukin 7 receptor","Interleukin-7 receptor subunit alpha","CD127","IL7RA","lnc-IL7R","IL-7Ralpha","IL7Ralpha","sIL-7R","CDw127"],"tldr":"IL7R (Interleukin-7 receptor subunit alpha) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Skin cancer, Leukaemia, Non-Hodgkin lymphoma and 5 more.","summary":"Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).\n\nCIViC holds 3 clinical evidence items and 0 assertions across 3 variants. Open Targets scores its association with cancer at 0.70 (direct and indirect evidence; datatypes literature 0.98, animal model 0.42, genetic association 0.36, somatic mutation 0.86). IntOGen calls it a driver in 4 cohorts (3 activating, 1 loss-of-function), covering Acute Lymphoblastic Leukaemia, Oesophageal Adenocarcinoma, Hepatocellular Carcinoma, Stomach Adenocarcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:6024","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6024"},{"label":"UniProt P16871","url":"https://www.uniprot.org/uniprotkb/P16871/entry"},{"label":"NCBI Gene 3575","url":"https://www.ncbi.nlm.nih.gov/gene/3575"},{"label":"Ensembl ENSG00000168685","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000168685"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets","intogen"],"cancers":["skin-cancer","leukaemia","non-hodgkin-lymphoma","esophageal","hcc","gastric","lung-cancer","all-leukemia"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 3 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 1 cohort; CIViC holds 3 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate.","Diseases the sources name that have no OnCo cancer page yet, so they are not linked: T-cell Acute Lymphoblastic Leukaemia; Childhood B-cell Acute Lymphoblastic Leukaemia; B-lymphoblastic Leukaemia/lymphoma, BCR-ABL1-like."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"IL7R","role":["oncogene-driver","tumour-suppressor","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:6024","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6024","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P16871","url":"https://www.uniprot.org/uniprotkb/P16871/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene IL7R","url":"https://civicdb.org/features/2975","note":"3 evidence items, 0 assertions, 3 variants; diseases: T-cell Acute Lymphoblastic Leukaemia, Childhood B-cell Acute Lymphoblastic Leukaemia, B-lymphoblastic Leukaemia/lymphoma, BCR-ABL1-like (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000168685","url":"https://platform.opentargets.org/target/ENSG00000168685/associations","note":"association with cancer (MONDO_0004992) 0.70; per-cancer scores at or above 0.5: melanoma 0.57, acute lymphoblastic leukaemia 0.59, non-Hodgkin lymphoma 0.61, skin cancer 0.64, lung cancer 0.56, leukaemia 0.62 (GraphQL API, CC0)"},{"label":"IntOGen IL7R","url":"https://www.intogen.org/search?gene=IL7R","note":"driver in 4 cohorts (Act 3, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"specificity":"tumour-specific","distribution":"many-types","specificityNote":"Tumour-specific alteration: the catalogues call it an oncogene driver (IntOGen cohort analysis finds it activated more often than chance) and a tumour suppressor (IntOGen finds it knocked out more often than chance), so the direction differs between cohorts but the alteration is somatic either way; what a medicine would aim at or exploit is the altered form or its loss, absent from normal cells; no corpus medicine is aimed at it yet. HPA IL7R: RNA tissue enhanced (lymphoid tissue 171 nTPM); blood lineage group enriched (NK-cells 113 nTPM, T-cells 370 nTPM); high antibody staining in 1 normal tissue. Distribution: 7 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Skin cancer (all types), Leukaemia, Lymphoma, Oesophageal cancer, Hepatocellular carcinoma, Gastric & gastro-oesophageal junction cancer, Lung cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 6 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"UniProt P16871","url":"https://www.uniprot.org/uniprotkb/P16871/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene IL7R","url":"https://civicdb.org/features/2975","note":"3 evidence items, 0 assertions, 3 variants; diseases: T-cell Acute Lymphoblastic Leukaemia, Childhood B-cell Acute Lymphoblastic Leukaemia, B-lymphoblastic Leukaemia/lymphoma, BCR-ABL1-like (GraphQL API, CC0)"},{"label":"IntOGen IL7R","url":"https://www.intogen.org/search?gene=IL7R","note":"driver in 4 cohorts (Act 3, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"},{"label":"Human Protein Atlas IL7R tissue","url":"https://www.proteinatlas.org/ENSG00000168685-IL7R/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000168685 associations","url":"https://platform.opentargets.org/target/ENSG00000168685/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:6024","ensembl":"ENSG00000168685","uniprot":"P16871","entrez":"3575","firstDescribed":1990,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Goodwin R.G. et al, Cell, 1990, \"Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/2317865/","biology":"Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP). Location: Cell membrane; Secreted (UniProt). Locus 5p13.2 (HGNC).","whereFound":["Skin cancer: Open Targets association 0.64 with skin cancer (MONDO_0002898)","Leukaemia: Open Targets association 0.62 with leukaemia (MONDO_0005059)","Non-Hodgkin lymphoma: Open Targets association 0.61 with non-Hodgkin lymphoma (MONDO_0018908)","Oesophageal cancer: IntOGen driver in 1 cohort (ESCA)","Hepatocellular carcinoma: IntOGen driver in 1 cohort (HCC)","Gastric & gastro-oesophageal junction cancer: IntOGen driver in 1 cohort (STAD)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/il7r/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"all-leukemia","kind":"cancer","name":"Acute lymphoblastic leukaemia","route":"/cancers/all-leukemia/"},{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"},{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"},{"id":"esophageal","kind":"cancer","name":"Oesophageal cancer","route":"/cancers/esophageal/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}