{"entity":{"id":"idea-tr2-reference-model-panels","kind":"idea","name":"Shared reference organoid and PDX panels that every lab can test against","aka":[],"tldr":"If every lab had access to the same set of well-characterised tumour models, results could be compared directly instead of each lab using its own private models.","summary":"Organoid and patient-derived xenograft results are hard to compare because models differ between labs. A curated reference panel (for example 50 organoids and 50 PDX models per major cancer, fully characterised, distributed at cost by a repository such as the Human Cancer Models Initiative or EurOPDX) with standard culture protocols and published baseline drug responses would serve as the common ground for method comparison and replication.","asOf":"2026-09-08","links":[{"label":"Human Cancer Models Initiative","url":"https://www.cancer.gov/ccg/research/functional-genomics/hcmi"},{"label":"EurOPDX","url":"https://www.europdx.eu/"}],"tags":[],"related":["cancer-models","idea-tr2-organoid-matrix-atlas","idea-tr2-reference-compound-panels"],"cancers":[],"sections":[],"technologies":["organoids","pdx-models"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":["b-reproducibility","b-preclinical-models"],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"hypothesis":"Drug-response results generated on the reference panel in different laboratories will show inter-laboratory concordance above 0.8, and findings validated on the panel will replicate more often than those on private models.","rationale":"Reference strains and lines underpin reproducibility in microbiology and immunology; oncology models have proliferated without a reference set.","test":"Distribute the panel to ten laboratories; run a common drug set; measure concordance; compare with historical cross-lab discordance.","maturity":"preclinical-evidence","actor":"philanthropy","cost":"medium","horizonYears":3},"route":"/ideas/idea-tr2-reference-model-panels/","neighbours":{"collection":[{"id":"cancer-models","kind":"collection","name":"Cancer Models (PDCM Finder) & HCMI","route":"/collections/cancer-models/"}],"idea":[{"id":"idea-tr2-organoid-matrix-atlas","kind":"idea","name":"A public atlas of drug-pair responses across a thousand patient-derived organoids","route":"/ideas/idea-tr2-organoid-matrix-atlas/"},{"id":"idea-tr2-reference-compound-panels","kind":"idea","name":"Every drug screen includes standard reference compounds whose performance is published","route":"/ideas/idea-tr2-reference-compound-panels/"}],"technology":[{"id":"organoids","kind":"technology","name":"Patient-derived organoids","route":"/technologies/organoids/"},{"id":"pdx-models","kind":"technology","name":"Patient-derived xenografts","route":"/technologies/pdx-models/"}],"bottleneck":[{"id":"b-preclinical-models","kind":"bottleneck","name":"Lab models that fail to predict what happens in patients","route":"/bottlenecks/b-preclinical-models/"},{"id":"b-reproducibility","kind":"bottleneck","name":"Preclinical results do not reproduce","route":"/bottlenecks/b-reproducibility/"}],"roadmap":[{"id":"drug-discovery-roadmap","kind":"roadmap","name":"Drug discovery roadmap: screening in mice → maps of dependency → designing in silico","route":"/roadmaps/drug-discovery-roadmap/"}]}}