{"entity":{"id":"idea-tr2-radiomics-ibsi-mandate","kind":"idea","name":"No clinical claims for imaging-derived biomarkers without phantom and standards compliance","aka":[],"tldr":"Thousands of papers extract 'radiomic' features from scans to predict outcomes, but the features change with scanner settings. Journals should require standard compliance before any clinical claim is made.","summary":"Radiomic features vary with acquisition, reconstruction and software; the Image Biomarker Standardisation Initiative (IBSI) defined reference values and benchmark datasets, but most published radiomics studies do not report compliance or test-retest reproducibility. Journals and funders requiring IBSI compliance, phantom-based feature stability testing and external validation for any radiomic biomarker claiming clinical relevance would cut the noise.","asOf":"2026-09-08","links":[{"label":"Image Biomarker Standardisation Initiative","url":"https://theibsi.github.io/"}],"tags":[],"related":["lunit","aidoc"],"cancers":[],"sections":[],"technologies":["ct","mri","pet-ct"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":["b-biomarker-validation","b-ai-validation"],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"hypothesis":"Adopting the requirement will reduce the number of published radiomic signatures by more than half and increase the fraction that replicate in external cohorts from a small minority to a majority.","rationale":"The field's replication crisis is well documented in systematic reviews; the standards exist and are unenforced.","test":"Two radiology journals adopt the requirement; compare external validation rates of signatures published before and after.","maturity":"early-clinical","actor":"research","cost":"small","horizonYears":2},"route":"/ideas/idea-tr2-radiomics-ibsi-mandate/","neighbours":{"company":[{"id":"aidoc","kind":"company","name":"Aidoc","route":"/companies/aidoc/"},{"id":"lunit","kind":"company","name":"Lunit","route":"/companies/lunit/"}],"technology":[{"id":"ct","kind":"technology","name":"CT (computed tomography)","route":"/technologies/ct/"},{"id":"mri","kind":"technology","name":"MRI","route":"/technologies/mri/"},{"id":"pet-ct","kind":"technology","name":"PET/CT","route":"/technologies/pet-ct/"}],"bottleneck":[{"id":"b-ai-validation","kind":"bottleneck","name":"AI that is built but not validated or deployed","route":"/bottlenecks/b-ai-validation/"},{"id":"b-biomarker-validation","kind":"bottleneck","name":"Biomarkers are not validated or standardised","route":"/bottlenecks/b-biomarker-validation/"}]}}