{"entity":{"id":"idea-data-toxicity-cds-for-nurses","kind":"idea","name":"Toxicity-management decision support for nurses and pharmacists","aka":[],"tldr":"Give the nurses and pharmacists who take patients' calls a tool that walks them through recognising and managing side effects of modern cancer drugs, including when to escalate.","summary":"Immunotherapy and targeted therapy toxicities are managed by triage nurses and pharmacists who may see a given drug rarely. Guideline-based toxicity algorithms (ESMO, ASCO, SITC) exist as tables. Encoding them as decision support integrated with ePRO alerts, with drug-specific pathways and escalation triggers, would standardise management and shorten time to steroids or hospital review for serious immune-related events.","asOf":"2026-09-08","links":[{"label":"Bottleneck evidence (Knowledge reaches practice too slowly): Morris, Wooding & Grant, The answer is 17 years, what is the question (JRSM 2011)","url":"https://doi.org/10.1258/jrsm.2011.110180"}],"tags":[],"related":["idea-data-pro-as-structured-standard"],"cancers":[],"sections":["ai-computation","supportive-care"],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["irae","crs"],"trials":[],"people":[],"bottlenecks":["b-knowledge-diffusion","b-toxicity-qol","b-workforce"],"keyPapers":["paper-morris-j-r-soc-med"],"journals":[],"dependsOn":[],"notes":[],"hypothesis":"Toxicity CDS will reduce time from symptom report to appropriate management and cut hospital admissions for grade 3 or higher immune-related adverse events by a meaningful margin.","rationale":"Delayed recognition of immune-related adverse events is a documented cause of morbidity; nurse-led triage with structured pathways has reduced admissions in single-centre studies.","test":"Deploy across a cancer network's triage lines for one year; compare admissions for immune-related events and time to intervention with the prior year and matched networks.","maturity":"early-clinical","actor":"clinic","cost":"small","horizonYears":2},"route":"/ideas/idea-data-toxicity-cds-for-nurses/","neighbours":{"idea":[{"id":"idea-data-pro-as-structured-standard","kind":"idea","name":"Patient-reported symptoms captured as standard structured data in every clinic","route":"/ideas/idea-data-pro-as-structured-standard/"}],"section":[{"id":"ai-computation","kind":"section","name":"AI & Computation","route":"/fronts/ai-computation/"},{"id":"supportive-care","kind":"section","name":"Supportive Care & Survivorship","route":"/fronts/supportive-care/"}],"term":[{"id":"crs","kind":"term","name":"Cytokine release syndrome (CRS)","route":"/terms/crs/"},{"id":"irae","kind":"term","name":"Immune-related adverse events (irAEs)","route":"/terms/irae/"}],"bottleneck":[{"id":"b-knowledge-diffusion","kind":"bottleneck","name":"Knowledge reaches practice too slowly","route":"/bottlenecks/b-knowledge-diffusion/"},{"id":"b-workforce","kind":"bottleneck","name":"Not enough oncologists, nurses, pathologists, physicists","route":"/bottlenecks/b-workforce/"},{"id":"b-toxicity-qol","kind":"bottleneck","name":"Toxicity and quality of life are undervalued","route":"/bottlenecks/b-toxicity-qol/"}],"paper":[{"id":"paper-morris-j-r-soc-med","kind":"paper","name":"The answer is 17 years, what is the question: understanding time lags in translational research","route":"/key-papers/paper-morris-j-r-soc-med/"}]}}