{"entity":{"id":"idea-data-structured-trial-results-deposit","kind":"idea","name":"Deposit trial results as structured data, not just PDFs","aka":[],"tldr":"Trial results (hazard ratios, confidence intervals, subgroups, toxicities) would be deposited in a computer-readable form so they can be pooled, checked and used by software immediately.","summary":"ClinicalTrials.gov results reporting is structured but coarse; journal articles are unstructured; Kaplan-Meier curves are images. The proposal requires deposition of a structured results package (primary and secondary endpoints with estimates and intervals, digitised survival curves or individual patient time-to-event data, subgroup tables, adverse events by grade in CTCAE codes) in a standard schema at publication, enabling automated meta-analysis and living guidelines.","asOf":"2026-09-08","links":[{"label":"Bottleneck evidence (Knowledge reaches practice too slowly): Morris, Wooding & Grant, The answer is 17 years, what is the question (JRSM 2011)","url":"https://doi.org/10.1258/jrsm.2011.110180"}],"tags":[],"related":["clinicaltrials-gov","idea-data-funded-living-systematic-reviews"],"cancers":[],"sections":["ai-computation"],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["hazard-ratio","os","pfs"],"trials":[],"people":[],"bottlenecks":["b-knowledge-diffusion","b-negative-results"],"keyPapers":["paper-morris-j-r-soc-med"],"journals":[],"dependsOn":[],"notes":[],"hypothesis":"Structured results deposition will make automated living meta-analysis possible for more than 80 percent of new phase 3 oncology trials and will reduce transcription errors in systematic reviews.","rationale":"Extraction from PDFs is the main cost and error source in evidence synthesis; every downstream use (living reviews, guidelines, knowledge graphs, decision support) is faster if results are born structured.","test":"Define the schema; require it for one year in two journals; measure the share of trials complying and the time to update a living review using the structured data versus PDF extraction.","maturity":"early-clinical","actor":"policy","cost":"small","horizonYears":2},"route":"/ideas/idea-data-structured-trial-results-deposit/","neighbours":{"collection":[{"id":"clinicaltrials-gov","kind":"collection","name":"ClinicalTrials.gov","route":"/collections/clinicaltrials-gov/"}],"idea":[{"id":"idea-data-full-data-with-abstract","kind":"idea","name":"End the abstract-to-paper gap: require full results with any conference presentation","route":"/ideas/idea-data-full-data-with-abstract/"},{"id":"idea-data-funded-living-systematic-reviews","kind":"idea","name":"Funded living systematic reviews for every major cancer indication","route":"/ideas/idea-data-funded-living-systematic-reviews/"}],"section":[{"id":"ai-computation","kind":"section","name":"AI & Computation","route":"/fronts/ai-computation/"}],"term":[{"id":"hazard-ratio","kind":"term","name":"Hazard ratio (HR)","route":"/terms/hazard-ratio/"},{"id":"os","kind":"term","name":"Overall survival (OS)","route":"/terms/os/"},{"id":"pfs","kind":"term","name":"Progression-free survival (PFS)","route":"/terms/pfs/"}],"bottleneck":[{"id":"b-negative-results","kind":"bottleneck","name":"Failures are hidden","route":"/bottlenecks/b-negative-results/"},{"id":"b-knowledge-diffusion","kind":"bottleneck","name":"Knowledge reaches practice too slowly","route":"/bottlenecks/b-knowledge-diffusion/"}],"paper":[{"id":"paper-morris-j-r-soc-med","kind":"paper","name":"The answer is 17 years, what is the question: understanding time lags in translational research","route":"/key-papers/paper-morris-j-r-soc-med/"}]}}