{"entity":{"id":"hpv-status","kind":"term","name":"HPV status (HPV-positive / HPV-negative)","aka":["HPV-positive","HPV positive","HPV-negative","HPV negative","HPV-driven","HPV-associated","HPV-related","high-risk HPV","HPV16","HPV 16","ctHPV","ctHPV DNA","HPV ctDNA","HPV DNA"],"tldr":"Whether a cancer is caused by human papillomavirus. HPV-positive throat cancers are a different, far more curable disease than smoking-related ones, and the virus's DNA in blood can track the cancer.","summary":"Persistent high-risk HPV (types 16 and 18 mainly) causes virtually all cervical cancer and rising shares of oropharyngeal, anal, vulval and penile cancers; p16 immunohistochemistry is the surrogate marker in the oropharynx. HPV-positive oropharyngeal cancer has 3-year survival above 80% and its own AJCC staging, so trials test de-escalating radiotherapy dose or omitting chemotherapy, none of which has yet succeeded in a randomised trial. Circulating HPV DNA (ctHPV) detects recurrence months before imaging. HPV vaccination and HPV-based cervical screening are the route to eliminating cervical cancer.","asOf":"2026-09-09","wikipedia":"https://en.wikipedia.org/wiki/Human_papillomavirus_infection","links":[{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/Human_papillomavirus_infection"}],"tags":[],"related":["head-neck-subsites","squamous-cell-carcinoma","dysplasia","ctdna"],"cancers":["head-and-neck","cervical"],"sections":["prevention","diagnostics"],"technologies":["hpv-vaccine"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"category":"Biomarkers"},"route":"/terms/hpv-status/","neighbours":{"term":[{"id":"ctdna","kind":"term","name":"Circulating tumour DNA (ctDNA)","route":"/terms/ctdna/"},{"id":"dysplasia","kind":"term","name":"Dysplasia (pre-cancerous change)","route":"/terms/dysplasia/"},{"id":"ebv-term","kind":"term","name":"Epstein-Barr virus (EBV) in cancer","route":"/terms/ebv-term/"},{"id":"extranodal-extension","kind":"term","name":"Extranodal extension (ENE)","route":"/terms/extranodal-extension/"},{"id":"head-neck-subsites","kind":"term","name":"Head and neck subsites (oral cavity, oropharynx, larynx)","route":"/terms/head-neck-subsites/"},{"id":"squamous-cell-carcinoma","kind":"term","name":"Squamous cell carcinoma","route":"/terms/squamous-cell-carcinoma/"}],"cancer":[{"id":"anal-hsil-precursor","kind":"cancer","name":"Anal high-grade squamous intraepithelial lesions (precursor)","route":"/cancers/anal-hsil-precursor/"},{"id":"cervical","kind":"cancer","name":"Cervical cancer","route":"/cancers/cervical/"},{"id":"early-cervical-cancer","kind":"cancer","name":"Early cervical cancer and fertility-sparing surgery","route":"/cancers/early-cervical-cancer/"},{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"},{"id":"localised-penile-cancer","kind":"cancer","name":"Localised penile cancer (organ-confined, node-negative)","route":"/cancers/localised-penile-cancer/"},{"id":"sinonasal","kind":"cancer","name":"Nasal cavity and paranasal sinus cancers (including esthesioneuroblastoma)","route":"/cancers/sinonasal/"},{"id":"node-positive-penile-cancer","kind":"cancer","name":"Node-positive and metastatic penile cancer","route":"/cancers/node-positive-penile-cancer/"},{"id":"penile","kind":"cancer","name":"Penile cancer","route":"/cancers/penile/"},{"id":"vaginal-adenocarcinoma","kind":"cancer","name":"Vaginal adenocarcinoma (including DES-associated clear cell adenocarcinoma)","route":"/cancers/vaginal-adenocarcinoma/"},{"id":"vaginal","kind":"cancer","name":"Vaginal cancer","route":"/cancers/vaginal/"},{"id":"vaginal-squamous-cell-carcinoma","kind":"cancer","name":"Vaginal squamous cell carcinoma (HPV-associated)","route":"/cancers/vaginal-squamous-cell-carcinoma/"}],"section":[{"id":"diagnostics","kind":"section","name":"Diagnostics & Biomarkers","route":"/fronts/diagnostics/"},{"id":"prevention","kind":"section","name":"Prevention & Risk","route":"/fronts/prevention/"}],"technology":[{"id":"hpv-vaccine","kind":"technology","name":"HPV & HBV vaccination","route":"/technologies/hpv-vaccine/"},{"id":"via-cervical-screening","kind":"technology","name":"Visual inspection with acetic acid (VIA) for cervical screening","route":"/technologies/via-cervical-screening/"}]}}