{"entity":{"id":"hoxa13","kind":"target","name":"HOXA13","aka":["homeobox A13","Homeobox protein Hox-A13","HOX1J","HOX1"],"tldr":"HOXA13 (Homeobox protein Hox-A13) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Sequence-specific, AT-rich binding transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.\n\nOpen Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.97, animal model 0.58, genetic association 0.25, somatic mutation 0.93). In OnCo, 1 product record names it (Cxbladder).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:5102","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5102"},{"label":"UniProt P31271","url":"https://www.uniprot.org/uniprotkb/P31271/entry"},{"label":"NCBI Gene 3209","url":"https://www.ncbi.nlm.nih.gov/gene/3209"},{"label":"Ensembl ENSG00000106031","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000106031"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":["cxbladder"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"HOXA13","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:5102","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5102","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P31271","url":"https://www.uniprot.org/uniprotkb/P31271/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000106031","url":"https://platform.opentargets.org/target/ENSG00000106031/associations","note":"association with cancer (MONDO_0004992) 0.63;  (GraphQL API, CC0)"}],"specificity":"tumour-associated","distribution":"not-established","specificityNote":"Tumour-associated overexpression: HPA finds the RNA cancer enhanced in cancer (Prostate Adenocarcinoma (TCGA)) and tissue enhanced in normal cervix, placenta, prostate, seminal vesicle, so the tumour and the normal tissue it comes from share the target and the medicine relies on the difference in level. HPA HOXA13: RNA tissue enhanced (cervix 21 nTPM, placenta 16 nTPM, prostate 21 nTPM); no normal tissue stained high. Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"Human Protein Atlas HOXA13 tissue","url":"https://www.proteinatlas.org/ENSG00000106031-HOXA13/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Human Protein Atlas HOXA13 pathology","url":"https://www.proteinatlas.org/ENSG00000106031-HOXA13/pathology","note":"patients per staining level per cancer type (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000106031 associations","url":"https://platform.opentargets.org/target/ENSG00000106031/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:5102","ensembl":"ENSG00000106031","uniprot":"P31271","entrez":"3209","firstDescribed":1989,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Acampora et al, Nucleic Acids Res, 1989, \"The human HOX gene family\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/2574852/","biology":"Sequence-specific, AT-rich binding transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Location: Nucleus (UniProt). Locus 7p15.2 (HGNC).","whereFound":[],"targetClass":"transcription","prevalence":[]},"route":"/targets/hoxa13/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"drug":[{"id":"cxbladder","kind":"drug","name":"Cxbladder","route":"/drugs/cxbladder/"}]}}