{"entity":{"id":"histosonics","kind":"company","name":"HistoSonics","aka":[],"tldr":"Inventor of histotripsy, non-invasive tumour destruction with focused ultrasound bubbles; acquired for $2.25B in 2025.","summary":"HistoSonics, based in Minneapolis, invented histotripsy, the non-invasive destruction of tumours with focused ultrasound bubbles, and was acquired for 2.25 billion dollars in 2025. Its Edison system received FDA authorisation for liver tumours in 2023, kidney and pancreas trials are under way, and the #HOPE4KIDNEY study is linked. OnCo connects it to focused ultrasound and histotripsy, to histotripsy as an immune primer, and to ideas on device-agnostic public trials of ablation against surgery and on pulverising one tumour to wake the immune system. Whether histotripsy shows a cancer-control benefit against established ablation and surgery in randomised trials is the open question. The technology page carries the detail.","asOf":"2026-09-04","links":[{"label":"Official website","url":"https://histosonics.com"}],"tags":[],"related":[],"cancers":[],"sections":["surgery","devices"],"technologies":["hifu-histotripsy"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"hq":"Minneapolis, MN","country":"US","companyType":"devices","website":"https://histosonics.com","investors":[],"funding":[]},"route":"/companies/histosonics/","neighbours":{"section":[{"id":"devices","kind":"section","name":"Devices & Physical Therapies","route":"/fronts/devices/"},{"id":"surgery","kind":"section","name":"Surgery & Interventional","route":"/fronts/surgery/"}],"technology":[{"id":"hifu-histotripsy","kind":"technology","name":"Focused ultrasound & histotripsy","route":"/technologies/hifu-histotripsy/"},{"id":"histotripsy-immune-priming","kind":"technology","name":"Histotripsy as an immune primer","route":"/technologies/histotripsy-immune-priming/"}],"idea":[{"id":"idea-fund-ablation-versus-surgery-trials","kind":"idea","name":"Device-agnostic public trials of ablation technologies against surgery","route":"/ideas/idea-fund-ablation-versus-surgery-trials/"},{"id":"idea-bio2-histotripsy-immune-priming","kind":"idea","name":"Mechanically pulverise one tumour with ultrasound to wake the immune system","route":"/ideas/idea-bio2-histotripsy-immune-priming/"}],"roadmap":[{"id":"devices-roadmap","kind":"roadmap","name":"Devices and physical therapies roadmap: heat and light → electric fields and focused sound → drug-releasing implants","route":"/roadmaps/devices-roadmap/"},{"id":"surgery-roadmap","kind":"roadmap","name":"Surgery roadmap: radical operations → less surgery → no surgery when a drug has done the work","route":"/roadmaps/surgery-roadmap/"}]}}