{"entity":{"id":"histiocyte-society","kind":"institution","name":"Histiocyte Society","aka":[],"tldr":"The international society of doctors and scientists who study histiocytic disorders; its LCH trials, run since the 1990s, set the worldwide standard for treating Langerhans cell histiocytosis in children.","summary":"Founded in 1985, the Histiocyte Society brings together clinicians and researchers working on Langerhans cell histiocytosis, haemophagocytic lymphohistiocytosis, Erdheim-Chester disease, Rosai-Dorfman disease and juvenile xanthogranuloma. It has run the sequential international LCH-I (1991), LCH-II, LCH-III (2001-2008) and LCH-IV trials, which established vinblastine-prednisone as standard therapy and defined its duration, and the HLH-94 and HLH-2004 protocols. It publishes classification and consensus guidelines, holds an annual scientific meeting, and maintains registries that supported the recognition of histiocytoses as MAPK-driven clonal neoplasms.","asOf":"2026-09-10","links":[{"label":"Histiocyte Society","url":"https://histiocytesociety.org"}],"tags":["nci-coverage","paediatric"],"related":[],"cancers":["langerhans-cell-histiocytosis","histiocytoses"],"sections":[],"technologies":[],"targets":[],"drugs":["vinblastine"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":["lch-iii"],"people":["vasanta-nanduri"],"bottlenecks":["b-rare-cancers"],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"city":"Pitman","country":"US","lat":39.733,"lng":-75.132,"institutionType":"consortium","website":"https://histiocytesociety.org","programs":["LCH-I to LCH-IV international trials","HLH-94 and HLH-2004 protocols","Histiocytosis classification and consensus guidelines","Annual meeting and registries"]},"route":"/institutions/histiocyte-society/","neighbours":{"cancer":[{"id":"histiocytoses","kind":"cancer","name":"Erdheim-Chester disease, Rosai-Dorfman disease and other histiocytic neoplasms","route":"/cancers/histiocytoses/"},{"id":"langerhans-cell-histiocytosis","kind":"cancer","name":"Langerhans cell histiocytosis (LCH)","route":"/cancers/langerhans-cell-histiocytosis/"}],"drug":[{"id":"vinblastine","kind":"drug","name":"Vinblastine","route":"/drugs/vinblastine/"}],"trial":[{"id":"lch-iii","kind":"trial","name":"LCH-III","route":"/trials/lch-iii/"}],"person":[{"id":"vasanta-nanduri","kind":"person","name":"Vasanta Nanduri","route":"/people/vasanta-nanduri/"}],"bottleneck":[{"id":"b-rare-cancers","kind":"bottleneck","name":"Rare and paediatric cancers without markets","route":"/bottlenecks/b-rare-cancers/"}]}}