{"entity":{"id":"hipec-at-interval-surgery","kind":"pairing","name":"HIPEC at interval cytoreductive surgery","aka":[],"tldr":"Heated intraperitoneal cisplatin during interval surgery, after neoadjuvant chemotherapy, extends survival in stage III disease.","summary":"Hyperthermic intraperitoneal chemotherapy delivered with platinum during interval cytoreductive surgery, after neoadjuvant chemotherapy for stage III ovarian cancer, is a combination pairing that extended survival in the phase 3 OVHIPEC-1 trial without additional major complications, and the benefit was confirmed at ten years of follow-up; a Korean trial is supportive. The rationale is direct high-dose exposure of residual microscopic peritoneal disease at the moment of maximal cytoreduction, with hyperthermia enhancing platinum uptake into tumour cells. The benefit appears specific to the interval-surgery setting. HIPEC at primary surgery is still being tested in OVHIPEC-2.","asOf":"2026-09-07","links":[{"label":"ClinicalTrials.gov NCT00426257: OVHIPEC-1","url":"https://clinicaltrials.gov/study/NCT00426257"}],"tags":[],"related":[],"cancers":["ovarian"],"sections":[],"technologies":["hipec"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":["ovhipec-1"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"a":"hipec","b":"carboplatin","rationale":"Direct high-dose exposure of residual microscopic peritoneal disease at the moment of maximal cytoreduction, with hyperthermia enhancing platinum uptake.","evidence":"Phase 3 with OS benefit; one supportive Korean trial.","pairingType":"combination"},"route":"/pairings/hipec-at-interval-surgery/","neighbours":{"cancer":[{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"}],"technology":[{"id":"hipec","kind":"technology","name":"HIPEC / PIPAC (intraperitoneal chemotherapy)","route":"/technologies/hipec/"}],"trial":[{"id":"ovhipec-1","kind":"trial","name":"OVHIPEC-1","route":"/trials/ovhipec-1/"}],"drug":[{"id":"carboplatin","kind":"drug","name":"Carboplatin","route":"/drugs/carboplatin/"}]}}