{"entity":{"id":"hhmi","kind":"institution","name":"Howard Hughes Medical Institute","aka":["HHMI"],"tldr":"The Howard Hughes Medical Institute funds scientists rather than projects through its Investigator Program; its roster has included Bert Vogelstein, William Kaelin, Charles Sawyers, Benjamin Ebert and Feng Zhang, the researchers behind colorectal cancer genetics, hypoxia sensing, kinase inhibitor resistance and CRISPR tools.","summary":"Founded in 1953 by Howard Hughes, HHMI is one of the largest private funders of biomedical research in the United States. Its Investigator Program gives long-term, flexible support to scientists at their home institutions, and its roster has included cancer researchers such as Bert Vogelstein (colorectal cancer genetics), William Kaelin (VHL and hypoxia sensing, Nobel 2019), Charles Sawyers (androgen receptor and kinase inhibitor resistance), Benjamin Ebert (lenalidomide's mechanism, clonal haematopoiesis) and Feng Zhang (CRISPR tools). HHMI also runs the Janelia Research Campus, the Hanna Gray and Freeman Hrabowski early-career fellowships, and it co-founded the open-access journal eLife.","asOf":"2026-09-09","links":[{"label":"HHMI","url":"https://www.hhmi.org"},{"label":"Investigators","url":"https://www.hhmi.org/scientists"}],"tags":[],"related":[],"cancers":[],"sections":["drug-discovery"],"technologies":["crispr-screens"],"targets":[],"drugs":[],"companies":[],"institutions":["johns-hopkins","dana-farber","mskcc","broad-institute"],"pathways":[],"terms":[],"trials":[],"people":["bert-vogelstein","william-kaelin","charles-sawyers","benjamin-ebert","feng-zhang","erin-oshea","david-baker"],"bottlenecks":["b-funding-allocation"],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"city":"Chevy Chase, MD","country":"US","lat":38.983,"lng":-77.086,"institutionType":"consortium","website":"https://www.hhmi.org","programs":["HHMI Investigator Program","Janelia Research Campus","Hanna Gray and Freeman Hrabowski fellowships","Open science (eLife, preprints)"]},"route":"/institutions/hhmi/","neighbours":{"section":[{"id":"drug-discovery","kind":"section","name":"Drug Discovery Platforms","route":"/fronts/drug-discovery/"}],"technology":[{"id":"crispr-screens","kind":"technology","name":"CRISPR functional genomics","route":"/technologies/crispr-screens/"}],"institution":[{"id":"broad-institute","kind":"institution","name":"Broad Institute of MIT and Harvard","route":"/institutions/broad-institute/"},{"id":"dana-farber","kind":"institution","name":"Dana-Farber Brigham Cancer Center","route":"/institutions/dana-farber/"},{"id":"johns-hopkins","kind":"institution","name":"Johns Hopkins Hospital / Sidney Kimmel Comprehensive Cancer Center","route":"/institutions/johns-hopkins/"},{"id":"mskcc","kind":"institution","name":"Memorial Sloan Kettering Cancer Center","route":"/institutions/mskcc/"}],"person":[{"id":"benjamin-ebert","kind":"person","name":"Benjamin L. Ebert","route":"/people/benjamin-ebert/"},{"id":"bert-vogelstein","kind":"person","name":"Bert Vogelstein","route":"/people/bert-vogelstein/"},{"id":"charles-sawyers","kind":"person","name":"Charles L. Sawyers","route":"/people/charles-sawyers/"},{"id":"david-baker","kind":"person","name":"David Baker","route":"/people/david-baker/"},{"id":"erin-oshea","kind":"person","name":"Erin K. O'Shea","route":"/people/erin-oshea/"},{"id":"feng-zhang","kind":"person","name":"Feng Zhang","route":"/people/feng-zhang/"},{"id":"michelle-monje","kind":"person","name":"Michelle Monje","route":"/people/michelle-monje/"},{"id":"reuben-shaw","kind":"person","name":"Reuben Shaw","route":"/people/reuben-shaw/"},{"id":"silvana-konermann","kind":"person","name":"Silvana Konermann","route":"/people/silvana-konermann/"},{"id":"william-kaelin","kind":"person","name":"William G. Kaelin Jr.","route":"/people/william-kaelin/"}],"bottleneck":[{"id":"b-funding-allocation","kind":"bottleneck","name":"Funding follows fashion, not burden","route":"/bottlenecks/b-funding-allocation/"}],"journal":[{"id":"elife","kind":"journal","name":"eLife","route":"/journals/elife/"}]}}