{"entity":{"id":"hgsoc","kind":"term","name":"High-grade serous ovarian carcinoma (HGSOC)","aka":[],"tldr":"High-grade serous ovarian carcinoma is the most common type of ovarian cancer and the one most often found late; it actually starts in the fallopian tube and almost always has a broken TP53 gene, and it is the type PARP inhibitors were built for.","summary":"The type behind about 70% of ovarian cancer deaths, and the one where maintenance therapy has changed the most. Near-universal TP53 mutation, ~50% homologous recombination deficiency (including ~20% BRCA1/2), extensive copy-number instability, few recurrent targetable mutations. Arises from serous tubal intraepithelial carcinoma, which is why opportunistic salpingectomy prevents it. PARP inhibitors, platinum, and FRα ADCs are the main therapeutic levers.","asOf":"2026-09-07","wikipedia":"https://en.wikipedia.org/wiki/High-grade_serous_carcinoma","links":[{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/High-grade_serous_carcinoma"}],"tags":[],"related":[],"cancers":["ovarian"],"sections":[],"technologies":[],"targets":["tp53","brca","folr1"],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["hrd"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"category":"Cancer biology"},"route":"/terms/hgsoc/","neighbours":{"cancer":[{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"}],"target":[{"id":"brca","kind":"target","name":"BRCA1 / BRCA2 (HRD)","route":"/targets/brca/"},{"id":"folr1","kind":"target","name":"Folate receptor alpha","route":"/targets/folr1/"},{"id":"tp53","kind":"target","name":"TP53","route":"/targets/tp53/"}],"term":[{"id":"hrd","kind":"term","name":"Homologous recombination deficiency (HRD)","route":"/terms/hrd/"}],"technology":[{"id":"risk-reducing-salpingectomy","kind":"technology","name":"Risk-reducing and opportunistic salpingectomy","route":"/technologies/risk-reducing-salpingectomy/"}],"person":[{"id":"gilda-radner","kind":"person","name":"Gilda Radner","route":"/people/gilda-radner/"}],"collection":[{"id":"ovarian-cancer-research-alliance","kind":"collection","name":"Ovarian Cancer Research Alliance (OCRA)","route":"/collections/ovarian-cancer-research-alliance/"}]}}