{"entity":{"id":"hbv-hcv","kind":"term","name":"Hepatitis B and C as cancer causes","aka":[],"tldr":"Two viruses cause most liver cancer worldwide. One is preventable by vaccine, the other curable with pills, which makes liver cancer one of the most preventable cancers.","summary":"HBV (integration and chronic inflammation) and HCV (chronic inflammation, cirrhosis) account for the majority of HCC globally. Universal HBV vaccination in Taiwan cut childhood HCC incidence by ~70%; direct-acting antivirals cure HCV in >95% and reduce HCC risk by roughly 70%, though risk persists in established cirrhosis. MASLD is now the fastest-growing cause in Western countries.","asOf":"2026-09-07","wikipedia":"https://en.wikipedia.org/wiki/Hepatitis_B","links":[{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/Hepatitis_B"}],"tags":[],"related":[],"cancers":["hcc"],"sections":[],"technologies":["hpv-vaccine","hcc-surveillance"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"category":"Epidemiology & prevention"},"route":"/terms/hbv-hcv/","neighbours":{"cancer":[{"id":"hcc-advanced","kind":"cancer","name":"Advanced hepatocellular carcinoma (BCLC C)","route":"/cancers/hcc-advanced/"},{"id":"hcc-early","kind":"cancer","name":"Early hepatocellular carcinoma (BCLC 0 and A)","route":"/cancers/hcc-early/"},{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"}],"technology":[{"id":"hcc-surveillance","kind":"technology","name":"HCC surveillance in cirrhosis (ultrasound + AFP)","route":"/technologies/hcc-surveillance/"},{"id":"hpv-vaccine","kind":"technology","name":"HPV & HBV vaccination","route":"/technologies/hpv-vaccine/"}],"pairing":[{"id":"io-varices-caution","kind":"pairing","name":"Caution: bevacizumab-based regimens with untreated varices","route":"/pairings/io-varices-caution/"}],"person":[{"id":"fan-jia","kind":"person","name":"Jia Fan","route":"/people/fan-jia/"}],"bottleneck":[{"id":"b-global-access","kind":"bottleneck","name":"Most of the world has almost no cancer care","route":"/bottlenecks/b-global-access/"},{"id":"b-prevention-adoption","kind":"bottleneck","name":"Prevention we already have is not deployed","route":"/bottlenecks/b-prevention-adoption/"}],"pathway":[{"id":"oncogenic-viruses","kind":"pathway","name":"Oncogenic viruses","route":"/pathways/oncogenic-viruses/"}],"trial":[{"id":"orient-32","kind":"trial","name":"ORIENT-32","route":"/trials/orient-32/"}]}}