{"entity":{"id":"hbegf","kind":"target","name":"HBEGF","aka":["heparin binding EGF like growth factor","Proheparin-binding EGF-like growth factor","HB-EGF","HEGFL"],"tldr":"HBEGF (Proheparin-binding EGF-like growth factor) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.","summary":"Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation.\n\nOpen Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.97, affected pathway 0.95, genetic association 0.00, clinical 0.08).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:3059","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3059"},{"label":"UniProt Q99075","url":"https://www.uniprot.org/uniprotkb/Q99075/entry"},{"label":"NCBI Gene 1839","url":"https://www.ncbi.nlm.nih.gov/gene/1839"},{"label":"Ensembl ENSG00000113070","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000113070"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.08. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"HBEGF","role":["drug-target"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:3059","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3059","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q99075","url":"https://www.uniprot.org/uniprotkb/Q99075/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000113070","url":"https://platform.opentargets.org/target/ENSG00000113070/associations","note":"association with cancer (MONDO_0004992) 0.61;  (GraphQL API, CC0)"}],"distribution":"not-established","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA HBEGF: RNA tissue enhanced (urinary bladder 120 nTPM); blood lineage group enriched (dendritic cells 2 nTPM, monocytes 2 nTPM); no normal tissue stained high; highest cancer staining melanoma (1 of 9 high). Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas HBEGF tissue","url":"https://www.proteinatlas.org/ENSG00000113070-HBEGF/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000113070 associations","url":"https://platform.opentargets.org/target/ENSG00000113070/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:3059","ensembl":"ENSG00000113070","uniprot":"Q99075","entrez":"1839","firstDescribed":1991,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Higashiyama et al, Science, 1991, \"A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/1840698/","biology":"Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Location: Secreted, extracellular space; Cell membrane (UniProt). Locus 5q31.3 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/hbegf/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}