{"entity":{"id":"harmonic-discovery","kind":"company","name":"Harmonic Discovery","aka":[],"tldr":"Harmonic Discovery designs single drugs that hit several disease-driving proteins at once, arguing that cancer is rarely caused by one broken protein.","summary":"Harmonic Discovery is a computational-experimental drug discovery company designing multi-targeted small molecules, principally kinase inhibitors, whose target profiles are chosen to hit several dysregulated proteins in a cancer at once while avoiding those that cause toxicity. The company argues that rational polypharmacology can be more effective and safer than one-drug-one-target agents. Programmes are preclinical; no sourced financing rounds are recorded here.","asOf":"2026-09-10","links":[{"label":"Y Combinator profile","url":"https://www.ycombinator.com/companies/harmonic-discovery"},{"label":"Official website","url":"https://harmonicdiscovery.com"}],"tags":["yc"],"related":[],"cancers":[],"sections":["drug-discovery","targeted-therapy"],"technologies":["ai-drug-design","kinase-inhibitors"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"hq":"New York, NY","country":"US","companyType":"biotech","website":"https://harmonicdiscovery.com","stage":"startup","ycBatch":"S21","investors":["y-combinator"],"funding":[]},"route":"/companies/harmonic-discovery/","neighbours":{"section":[{"id":"drug-discovery","kind":"section","name":"Drug Discovery Platforms","route":"/fronts/drug-discovery/"},{"id":"targeted-therapy","kind":"section","name":"Targeted Therapy","route":"/fronts/targeted-therapy/"}],"technology":[{"id":"ai-drug-design","kind":"technology","name":"AI-driven drug & target discovery","route":"/technologies/ai-drug-design/"},{"id":"kinase-inhibitors","kind":"technology","name":"Small-molecule kinase inhibitors","route":"/technologies/kinase-inhibitors/"}],"company":[{"id":"y-combinator","kind":"company","name":"Y Combinator","route":"/companies/y-combinator/"}]}}