{"entity":{"id":"h2bc5","kind":"target","name":"H2BC5","aka":["H2B clustered histone 5","Histone H2B type 1-D","H2B/b","H2BFB","HIST1H2BD"],"tldr":"H2BC5 (Histone H2B type 1-D) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.","summary":"Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:4747","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4747"},{"label":"UniProt P58876","url":"https://www.uniprot.org/uniprotkb/P58876/entry"},{"label":"NCBI Gene 3017","url":"https://www.ncbi.nlm.nih.gov/gene/3017"},{"label":"Ensembl ENSG00000158373","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000158373"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["dlbcl"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"H2BC5","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:4747","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4747","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P58876","url":"https://www.uniprot.org/uniprotkb/P58876/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene H2BC5","url":"https://civicdb.org/features/2535","note":"1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0)"}],"specificity":"broadly-expressed","distribution":"one-type","specificityNote":"Broadly expressed or essential: HPA lists H2BC5 among essential proteins and finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA H2BC5: RNA low tissue specificity; high antibody staining in 44 normal tissues; highest cancer staining glioma (11 of 11 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lymphoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"Human Protein Atlas H2BC5 tissue","url":"https://www.proteinatlas.org/ENSG00000158373-H2BC5/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000158373 associations","url":"https://platform.opentargets.org/target/ENSG00000158373/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:4747","ensembl":"ENSG00000158373","uniprot":"P58876","entrez":"3017","firstDescribed":1991,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Albig et al, Genomics, 1991, \"Isolation and characterization of two human H1 histone genes within clusters of core histone genes\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/1916825/","biology":"Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Location: Nucleus; Chromosome (UniProt). Locus 6p22.2 (HGNC).","whereFound":["Diffuse large B-cell lymphoma: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/h2bc5/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"dlbcl","kind":"cancer","name":"Diffuse large B-cell lymphoma","route":"/cancers/dlbcl/"}]}}