{"entity":{"id":"h1-5","kind":"target","name":"H1-5","aka":["H1.5 linker histone, cluster member","Histone H1.5","H1b","H1s-3","H1F5","HIST1H1B"],"tldr":"H1-5 (Histone H1.5) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.","summary":"Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fibre. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibres and promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:4719","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4719"},{"label":"UniProt P16401","url":"https://www.uniprot.org/uniprotkb/P16401/entry"},{"label":"NCBI Gene 3009","url":"https://www.ncbi.nlm.nih.gov/gene/3009"},{"label":"Ensembl ENSG00000184357","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000184357"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["dlbcl"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"H1-5","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:4719","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4719","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P16401","url":"https://www.uniprot.org/uniprotkb/P16401/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene H1-5","url":"https://civicdb.org/features/2529","note":"1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0)"}],"distribution":"one-type","specificityNote":"Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role biomarker; HPA finds the RNA group enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA H1-5: RNA group enriched (bone marrow 7 nTPM, lymphoid tissue 2 nTPM); blood lineage group enriched (B-cells 10 nTPM, dendritic cells 12 nTPM, T-cells 3 nTPM); high antibody staining in 24 normal tissues; highest cancer staining endometrial cancer (11 of 11 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Lymphoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)","specificitySources":[{"label":"Human Protein Atlas H1-5 tissue","url":"https://www.proteinatlas.org/ENSG00000184357-H1-5/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000184357 associations","url":"https://platform.opentargets.org/target/ENSG00000184357/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:4719","ensembl":"ENSG00000184357","uniprot":"P16401","entrez":"3009","firstDescribed":1989,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Ohe et al, J. Biochem, 1989, \"Human spleen histone H1. Isolation and amino acid sequences of three minor variants, H1a, H1c, and H1d\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/2613692/","biology":"Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fibre. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibres and promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation. Location: Nucleus; Chromosome (UniProt). Locus 6p22.1 (HGNC).","whereFound":["Diffuse large B-cell lymphoma: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/h1-5/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"dlbcl","kind":"cancer","name":"Diffuse large B-cell lymphoma","route":"/cancers/dlbcl/"}]}}