{"entity":{"id":"gustave-roussy","kind":"institution","name":"Gustave Roussy","aka":[],"tldr":"Gustave Roussy, outside Paris, is Europe's largest cancer centre; its DITEP phase 1 unit and its breast antibody-drug conjugate and immunotherapy trials (trastuzumab deruxtecan, datopotamab deruxtecan) make it a lead site for industry studies, and it created the ESMO-MCBS scale for grading how much benefit a new drug offers.","summary":"Gustave Roussy in Villejuif, outside Paris, is Europe's largest cancer centre and ranks sixth in the Newsweek/Statista World's Best Specialized Hospitals list for oncology. It houses the DITEP phase 1 unit, holds a Paris-Saclay affiliation, and has led breast antibody-drug conjugate work on trastuzumab deruxtecan and datopotamab deruxtecan alongside a strong immuno-oncology programme, with Fabrice André, Caroline Robert, Laurence Albiges and Martin Schlumberger among its clinicians. OnCo links it to PEACE-1 and ESTIMABL2, to the Inter-B-NHL Ritux 2010 paediatric lymphoma trial, to the ITCC paediatric network, and to ideas on microbiome transplant and the timing of immunotherapy dosing. How an academic centre keeps independent judgement while leading so many industry-sponsored trials is a live question. Its phase 1 unit is the part most visitors come to see.","asOf":"2026-09-04","wikipedia":"https://en.wikipedia.org/wiki/Institut_Gustave_Roussy","links":[{"label":"Official website","url":"https://www.gustaveroussy.fr"}],"tags":[],"related":[],"cancers":[],"sections":[],"technologies":["zap-x","radiosurgery-srs"],"targets":[],"drugs":["trastuzumab-deruxtecan","datopotamab-deruxtecan"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":["fabrice-andre","laurence-albiges","caroline-robert","martin-schlumberger","aurelien-marabelle","benjamin-besse","fabrice-barlesi","jean-charles-soria","karim-fizazi","laurence-zitvogel"],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"city":"Villejuif","country":"FR","lat":48.795,"lng":2.349,"institutionType":"cancer-center","website":"https://www.gustaveroussy.fr","newsweekOncology2026":6,"programs":["Phase 1 (DITEP)","Breast ADC trials","Immuno-oncology"]},"route":"/institutions/gustave-roussy/","neighbours":{"technology":[{"id":"radiosurgery-srs","kind":"technology","name":"Stereotactic radiosurgery (Gamma Knife, CyberKnife, linac SRS)","route":"/technologies/radiosurgery-srs/"},{"id":"zap-x","kind":"technology","name":"ZAP-X gyroscopic radiosurgery","route":"/technologies/zap-x/"}],"drug":[{"id":"datopotamab-deruxtecan","kind":"drug","name":"Datopotamab deruxtecan","route":"/drugs/datopotamab-deruxtecan/"},{"id":"trastuzumab-deruxtecan","kind":"drug","name":"Trastuzumab deruxtecan","route":"/drugs/trastuzumab-deruxtecan/"}],"person":[{"id":"alexander-eggermont","kind":"person","name":"Alexander Eggermont","route":"/people/alexander-eggermont/"},{"id":"aurelien-marabelle","kind":"person","name":"Aurélien Marabelle","route":"/people/aurelien-marabelle/"},{"id":"benjamin-besse","kind":"person","name":"Benjamin Besse","route":"/people/benjamin-besse/"},{"id":"caroline-robert","kind":"person","name":"Caroline Robert","route":"/people/caroline-robert/"},{"id":"fabrice-andre","kind":"person","name":"Fabrice André","route":"/people/fabrice-andre/"},{"id":"fabrice-barlesi","kind":"person","name":"Fabrice Barlesi","route":"/people/fabrice-barlesi/"},{"id":"gilles-vassal","kind":"person","name":"Gilles Vassal","route":"/people/gilles-vassal/"},{"id":"jacques-grill","kind":"person","name":"Jacques Grill","route":"/people/jacques-grill/"},{"id":"jean-charles-soria","kind":"person","name":"Jean-Charles Soria","route":"/people/jean-charles-soria/"},{"id":"julien-hadoux","kind":"person","name":"Julien Hadoux","route":"/people/julien-hadoux/"},{"id":"karim-fizazi","kind":"person","name":"Karim Fizazi","route":"/people/karim-fizazi/"},{"id":"laurence-albiges","kind":"person","name":"Laurence Albiges","route":"/people/laurence-albiges/"},{"id":"laurence-zitvogel","kind":"person","name":"Laurence Zitvogel","route":"/people/laurence-zitvogel/"},{"id":"martin-schlumberger","kind":"person","name":"Martin Schlumberger","route":"/people/martin-schlumberger/"},{"id":"patricia-pautier","kind":"person","name":"Patricia Pautier","route":"/people/patricia-pautier/"}],"cancer":[{"id":"dlbcl","kind":"cancer","name":"Diffuse large B-cell lymphoma","route":"/cancers/dlbcl/"},{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"},{"id":"rcc","kind":"cancer","name":"Renal cell carcinoma","route":"/cancers/rcc/"},{"id":"sarcoma","kind":"cancer","name":"Sarcomas (soft tissue, bone, GIST)","route":"/cancers/sarcoma/"},{"id":"sclc","kind":"cancer","name":"Small-cell lung cancer","route":"/cancers/sclc/"},{"id":"thyroid","kind":"cancer","name":"Thyroid cancer","route":"/cancers/thyroid/"}],"trial":[{"id":"estimabl2","kind":"trial","name":"ESTIMABL2","route":"/trials/estimabl2/"},{"id":"firstmappp","kind":"trial","name":"FIRSTMAPPP","route":"/trials/firstmappp/"},{"id":"inter-b-nhl-ritux-2010","kind":"trial","name":"Inter-B-NHL Ritux 2010","route":"/trials/inter-b-nhl-ritux-2010/"},{"id":"peace-1","kind":"trial","name":"PEACE-1","route":"/trials/peace-1/"},{"id":"prophylochip","kind":"trial","name":"PROPHYLOCHIP-PRODIGE 15","route":"/trials/prophylochip/"},{"id":"winther","kind":"trial","name":"WINTHER","route":"/trials/winther/"}],"company":[{"id":"french-sarcoma-group","kind":"company","name":"French Sarcoma Group","route":"/companies/french-sarcoma-group/"},{"id":"itcc","kind":"company","name":"Innovative Therapies for Children with Cancer (ITCC)","route":"/companies/itcc/"},{"id":"ifct","kind":"company","name":"Intergroupe Francophone de Cancérologie Thoracique","route":"/companies/ifct/"},{"id":"sengine","kind":"company","name":"SEngine Precision Medicine","route":"/companies/sengine/"},{"id":"unicancer","kind":"company","name":"UNICANCER","route":"/companies/unicancer/"}],"idea":[{"id":"idea-fund-global-academic-phase-one-network","kind":"idea","name":"A global first-in-human network for academic cancer trials with single ethics review","route":"/ideas/idea-fund-global-academic-phase-one-network/"},{"id":"idea-tr1-tumour-board-trial-line-item","kind":"idea","name":"A mandatory trial line in every tumour board recommendation","route":"/ideas/idea-tr1-tumour-board-trial-line-item/"},{"id":"idea-chronotherapy-immunotherapy","kind":"idea","name":"Give immunotherapy in the morning","route":"/ideas/idea-chronotherapy-immunotherapy/"},{"id":"idea-microbiome-io-fmt","kind":"idea","name":"Microbiome transplant as a routine immunotherapy adjunct","route":"/ideas/idea-microbiome-io-fmt/"},{"id":"idea-bio2-fmt-plus-checkpoint-phase3","kind":"idea","name":"Take faecal transplant plus immunotherapy to a definitive trial","route":"/ideas/idea-bio2-fmt-plus-checkpoint-phase3/"},{"id":"idea-immune-exclusion-drivers","kind":"idea","name":"What actually holds T cells at the tumour border?","route":"/ideas/idea-immune-exclusion-drivers/"}],"pathway":[{"id":"microbiome-tumour","kind":"pathway","name":"Microbiome-tumour interactions","route":"/pathways/microbiome-tumour/"}],"paper":[{"id":"paper-flaura-nejm-2018","kind":"paper","name":"FLAURA: osimertinib as first treatment for EGFR-mutated lung cancer","route":"/key-papers/paper-flaura-nejm-2018/"}],"institution":[{"id":"aphp-paris-saclay-cancer-institute","kind":"institution","name":"AP-HP Paris-Saclay University Hospitals Cancer Institute","route":"/institutions/aphp-paris-saclay-cancer-institute/"},{"id":"fondation-arc","kind":"institution","name":"Fondation ARC pour la recherche sur le cancer","route":"/institutions/fondation-arc/"},{"id":"has-france","kind":"institution","name":"Haute Autorité de Santé","route":"/institutions/has-france/"},{"id":"inca","kind":"institution","name":"Institut National du Cancer","route":"/institutions/inca/"},{"id":"institut-pasteur","kind":"institution","name":"Institut Pasteur","route":"/institutions/institut-pasteur/"},{"id":"ligue-contre-le-cancer","kind":"institution","name":"Ligue nationale contre le cancer","route":"/institutions/ligue-contre-le-cancer/"},{"id":"oeci","kind":"institution","name":"Organisation of European Cancer Institutes","route":"/institutions/oeci/"}]}}