{"entity":{"id":"guardian-bio","kind":"company","name":"Guardian Bio","aka":[],"tldr":"Guardian Bio turns a patient's stem cells into dendritic cells, the immune system's teachers, trains them against that patient's tumour and gives them back to restart the immune attack.","summary":"Guardian Bio is developing a dendritic cell therapy platform: patient-derived stem cells are differentiated into therapeutic dendritic cells, loaded against multiple antigens from the patient's own tumour and reinfused to activate cytotoxic T cells and natural killer cells. The rationale is that dendritic cell dysfunction in cancer patients limits the effect of other immunotherapies. The company is preclinical with a very small team; no sourced financing rounds are recorded.","asOf":"2026-09-10","links":[{"label":"Y Combinator profile","url":"https://www.ycombinator.com/companies/guardian-bio"},{"label":"Official website","url":"https://www.guardian-bio.com"}],"tags":["yc"],"related":[],"cancers":[],"sections":["cell-therapy","immunotherapy"],"technologies":["allogeneic-cell-therapy","shared-antigen-vaccine"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"hq":"Boston, MA","country":"US","companyType":"cell-therapy","website":"https://www.guardian-bio.com","stage":"startup","ycBatch":"S22","investors":["y-combinator"],"funding":[]},"route":"/companies/guardian-bio/","neighbours":{"section":[{"id":"cell-therapy","kind":"section","name":"Cell Therapy","route":"/fronts/cell-therapy/"},{"id":"immunotherapy","kind":"section","name":"Immunotherapy","route":"/fronts/immunotherapy/"}],"technology":[{"id":"allogeneic-cell-therapy","kind":"technology","name":"Allogeneic (off-the-shelf) cell therapy","route":"/technologies/allogeneic-cell-therapy/"},{"id":"shared-antigen-vaccine","kind":"technology","name":"Off-the-shelf cancer vaccines","route":"/technologies/shared-antigen-vaccine/"}],"company":[{"id":"y-combinator","kind":"company","name":"Y Combinator","route":"/companies/y-combinator/"}]}}