{"entity":{"id":"grade-vs-stage","kind":"term","name":"Grade versus stage","aka":["grade vs stage","grade and stage","grading versus staging","tumour grade versus stage"],"tldr":"Grade describes how abnormal the cancer cells look under the microscope; stage describes how far the cancer has grown and spread.","summary":"Grading, per the Wikipedia article, is a pathologist's measure of how much the tumour cells resemble the normal tissue they came from (differentiation), from low grade to high grade. Staging is the separate process of determining the extent of growth and spread, usually as a number from I to IV built from tumour size, invasion, lymph nodes and metastasis. Both are routine clinical covariates in prognostic models, and models that mix them up mis-state what they predict.","asOf":"2026-09-24","wikipedia":"https://en.wikipedia.org/wiki/Grading_(tumors)","links":[{"label":"Wikipedia: cancer staging","url":"https://en.wikipedia.org/wiki/Cancer_staging"},{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/Grading_(tumors)"}],"tags":["cansim-terms"],"related":["cancer-ai-vocabulary","grade-stage-receptor-breast"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["cancer-stage","tnm-staging","tumour-differentiation","grade-stage-receptor-breast","nottingham-grade"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Listed in the CanSim terms map 1.0.0 (docs/onco/terms.json, generated 2026-09-24), CC BY 4.0, attribution: CanSim project, an open, public-data-first cancer foundation-model programme; CanSim page path /terms/grade-vs-stage."],"provenance":{"editedBy":"OnCo CanSim terms wave (Wikipedia summaries, standards and project pages, GDC and FDA pages, Europe PMC)","editedOn":"2026-09-24","note":"CanSim terms map 1.0.0 (docs/onco/terms.json, generated 2026-09-24), CC BY 4.0, attribution: CanSim project, an open, public-data-first cancer foundation-model programme"},"category":"Pathology"},"route":"/terms/grade-vs-stage/","neighbours":{"term":[{"id":"ajcc-stage","kind":"term","name":"AJCC stage (TNM staging manual)","route":"/terms/ajcc-stage/"},{"id":"cancer-ai-vocabulary","kind":"term","name":"Cancer AI vocabulary (CanSim terms map)","route":"/terms/cancer-ai-vocabulary/"},{"id":"clinical-covariates","kind":"term","name":"Clinical covariates (age, stage, nodes, treatment flags)","route":"/terms/clinical-covariates/"},{"id":"grade-stage-receptor-breast","kind":"term","name":"Grade, stage and receptor status: three different things on one breast report","route":"/terms/grade-stage-receptor-breast/"},{"id":"nottingham-grade","kind":"term","name":"Nottingham grade (breast cancer grade 1, 2 and 3)","route":"/terms/nottingham-grade/"},{"id":"cancer-stage","kind":"term","name":"Stage","route":"/terms/cancer-stage/"},{"id":"tnm-staging","kind":"term","name":"TNM staging","route":"/terms/tnm-staging/"},{"id":"tnm-prostate-cancer","kind":"term","name":"TNM staging for prostate cancer, and what changed in the 9th edition","route":"/terms/tnm-prostate-cancer/"},{"id":"tumour-differentiation","kind":"term","name":"Tumour differentiation (well / moderately / poorly differentiated)","route":"/terms/tumour-differentiation/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}]}}