{"entity":{"id":"fred-hutch","kind":"institution","name":"Fred Hutchinson Cancer Center","aka":[],"tldr":"Birthplace of bone marrow transplantation (Thomas, Nobel 1990) and a CAR-T pioneer (Riddell).","summary":"Fred Hutchinson Cancer Center in Seattle, NCI-designated as comprehensive and tied to the University of Washington, is the birthplace of bone marrow transplantation, for which Thomas won the Nobel Prize in 1990, and a CAR-T pioneer through Stanley R. Riddell and Philip D. Greenberg, whose work fed the origins of Juno. It runs HPV vaccine trials, the SWOG statistical centre and the Hutch Cancer Immunotherapy Integrated Research Center, with Denise A. Galloway, Joseph M. Unger, Hans-Peter Kiem and Gary H. Lyman also listed. OnCo links it to the cancer cachexia and RNA splicing pathways, to Unger's paper on how few patients are ever offered a trial, and to the Uganda Cancer Institute. Whether splice-derived neoantigens can become off-the-shelf vaccine targets is one open question it is linked to. Its transplant, CAR-T and SWOG programmes are listed below.","asOf":"2026-09-04","wikipedia":"https://en.wikipedia.org/wiki/Fred_Hutchinson_Cancer_Center","links":[{"label":"Official website","url":"https://www.fredhutch.org"},{"label":"PTCOG: particle therapy facilities in operation","url":"https://www.ptcog.site/index.php/facilities-in-operation-public"}],"tags":[],"related":[],"cancers":[],"sections":[],"technologies":["car-t","proton-therapy","proton-therapy-systems"],"targets":[],"drugs":[],"companies":["blaze-bioscience"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":["thomas-lynch","stanley-riddell","michael-leblanc","philip-greenberg","hans-peter-kiem","gary-lyman","joseph-unger","denise-galloway","sara-hurvitz"],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"city":"Seattle","country":"US","lat":47.627,"lng":-122.332,"institutionType":"cancer-center","website":"https://www.fredhutch.org","nci":"comprehensive","university":"University of Washington","programs":["Transplant","CAR-T","SWOG"]},"route":"/institutions/fred-hutch/","neighbours":{"technology":[{"id":"car-t","kind":"technology","name":"CAR-T cell therapy","route":"/technologies/car-t/"},{"id":"proton-therapy","kind":"technology","name":"Proton therapy","route":"/technologies/proton-therapy/"},{"id":"proton-therapy-systems","kind":"technology","name":"Proton therapy machines: cyclotrons, synchrotrons and single-room systems","route":"/technologies/proton-therapy-systems/"}],"company":[{"id":"blaze-bioscience","kind":"company","name":"Blaze Bioscience","route":"/companies/blaze-bioscience/"},{"id":"swog","kind":"company","name":"SWOG Cancer Research Network","route":"/companies/swog/"}],"person":[{"id":"denise-galloway","kind":"person","name":"Denise A. Galloway","route":"/people/denise-galloway/"},{"id":"douglas-hawkins","kind":"person","name":"Douglas S. Hawkins","route":"/people/douglas-hawkins/"},{"id":"gary-lyman","kind":"person","name":"Gary H. Lyman","route":"/people/gary-lyman/"},{"id":"hans-peter-kiem","kind":"person","name":"Hans-Peter Kiem","route":"/people/hans-peter-kiem/"},{"id":"joseph-unger","kind":"person","name":"Joseph M. Unger","route":"/people/joseph-unger/"},{"id":"michael-leblanc","kind":"person","name":"Michael LeBlanc","route":"/people/michael-leblanc/"},{"id":"philip-greenberg","kind":"person","name":"Philip D. Greenberg","route":"/people/philip-greenberg/"},{"id":"sara-hurvitz","kind":"person","name":"Sara A. Hurvitz","route":"/people/sara-hurvitz/"},{"id":"shailender-bhatia","kind":"person","name":"Shailender Bhatia","route":"/people/shailender-bhatia/"},{"id":"stanley-riddell","kind":"person","name":"Stanley R. Riddell","route":"/people/stanley-riddell/"},{"id":"thomas-lynch","kind":"person","name":"Thomas J. Lynch Jr.","route":"/people/thomas-lynch/"}],"paper":[{"id":"paper-pritchard-inherited-dna-repair-metastatic-prostate-nejm-2016","kind":"paper","name":"Inherited DNA-repair gene mutations in men with metastatic prostate cancer","route":"/key-papers/paper-pritchard-inherited-dna-repair-metastatic-prostate-nejm-2016/"},{"id":"paper-unger-trial-participation-barriers-jnci-2019","kind":"paper","name":"Unger: most patients never get the chance to join a cancer trial, and when offered, half say yes","route":"/key-papers/paper-unger-trial-participation-barriers-jnci-2019/"}],"institution":[{"id":"nci","kind":"institution","name":"National Cancer Institute (NIH)","route":"/institutions/nci/"},{"id":"parker-institute","kind":"institution","name":"Parker Institute for Cancer Immunotherapy","route":"/institutions/parker-institute/"},{"id":"seattle-childrens","kind":"institution","name":"Seattle Children's Hospital","route":"/institutions/seattle-childrens/"},{"id":"uganda-cancer-institute","kind":"institution","name":"Uganda Cancer Institute","route":"/institutions/uganda-cancer-institute/"}],"pathway":[{"id":"cachexia-biology","kind":"pathway","name":"Cancer cachexia","route":"/pathways/cachexia-biology/"},{"id":"rna-splicing","kind":"pathway","name":"RNA splicing","route":"/pathways/rna-splicing/"}],"idea":[{"id":"idea-splice-neoantigens","kind":"idea","name":"Shared splice-derived neoantigens as off-the-shelf vaccine targets","route":"/ideas/idea-splice-neoantigens/"},{"id":"idea-cachexia-gdf15-prevention","kind":"idea","name":"Treat cachexia before it starts","route":"/ideas/idea-cachexia-gdf15-prevention/"}]}}