{"entity":{"id":"foxp1","kind":"target","name":"FOXP1","aka":["forkhead box P1","Forkhead box protein P1","QRF1","12CC4","HSPC215","hFKH1B"],"tldr":"FOXP1 (Forkhead box protein P1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, a biomarker and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Skin cancer, Breast cancer, Prostate cancer and 5 more.","summary":"Transcriptional repressor. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays an important role in the specification and differentiation of lung epithelium.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.76 (direct and indirect evidence; datatypes literature 0.99, genetic association 0.67, somatic mutation 0.86). IntOGen calls it a driver in 2 cohorts (0 activating, 2 loss-of-function), covering Invasive Breast Carcinoma, Prostate Adenocarcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:3823","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3823"},{"label":"UniProt Q9H334","url":"https://www.uniprot.org/uniprotkb/Q9H334/entry"},{"label":"NCBI Gene 27086","url":"https://www.ncbi.nlm.nih.gov/gene/27086"},{"label":"Ensembl ENSG00000114861","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000114861"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets","intogen"],"cancers":["skin-cancer","breast-cancer","prostate","neuroendocrine","gastric","ovarian","esophageal","biliary-tract-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts; CIViC holds 1 clinical evidence items on its variants; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"FOXP1","role":["tumour-suppressor","biomarker","fusion-partner"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:3823","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3823","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9H334","url":"https://www.uniprot.org/uniprotkb/Q9H334/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene FOXP1","url":"https://civicdb.org/features/56","note":"1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000114861","url":"https://platform.opentargets.org/target/ENSG00000114861/associations","note":"association with cancer (MONDO_0004992) 0.76; per-cancer scores at or above 0.5: gastric cancer 0.52, oesophageal cancer 0.51, prostate cancer 0.56, ovarian cancer 0.51, melanoma 0.64, neuroendocrine neoplasm 0.52 (GraphQL API, CC0)"},{"label":"IntOGen FOXP1","url":"https://www.intogen.org/search?gene=FOXP1","note":"driver in 2 cohorts (Act 0, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"specificity":"tumour-specific","distribution":"many-types","specificityNote":"Tumour-specific alteration: the catalogues call it a tumour suppressor (IntOGen finds it knocked out more often than chance) and a fusion partner (UniProt records a translocation); what a medicine would aim at or exploit is the altered form or its loss, absent from normal cells; no corpus medicine is aimed at it yet. HPA FOXP1: RNA low tissue specificity; high antibody staining in 24 normal tissues; highest cancer staining colorectal cancer (7 of 12 high). Distribution: 8 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Skin cancer (all types), Breast cancer (all types), Prostate cancer, Neuroendocrine tumours, Gastric & gastro-oesophageal junction cancer, Ovarian cancer, Oesophageal cancer and more); Open Targets associates it with 1 specific cancer type at or above 0.5 (skin cancer). (Rule 6 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"UniProt Q9H334","url":"https://www.uniprot.org/uniprotkb/Q9H334/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene FOXP1","url":"https://civicdb.org/features/56","note":"1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0)"},{"label":"IntOGen FOXP1","url":"https://www.intogen.org/search?gene=FOXP1","note":"driver in 2 cohorts (Act 0, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"},{"label":"Human Protein Atlas FOXP1 tissue","url":"https://www.proteinatlas.org/ENSG00000114861-FOXP1/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000114861 associations","url":"https://platform.opentargets.org/target/ENSG00000114861/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:3823","ensembl":"ENSG00000114861","uniprot":"Q9H334","entrez":"27086","firstDescribed":2000,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Zhang Q.-H. et al, Genome Res, 2000, \"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/11042152/","biology":"Transcriptional repressor. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Location: Nucleus (UniProt). Locus 3p13 (HGNC).","whereFound":["Skin cancer: Open Targets association 0.68 with skin cancer (MONDO_0002898)","Breast cancer: Open Targets association 0.66 with breast cancer (MONDO_0007254); IntOGen driver in 1 cohort (BRCA)","Prostate cancer: Open Targets association 0.56 with prostate cancer (MONDO_0008315); IntOGen driver in 1 cohort (PRAD)","Neuroendocrine tumours: Open Targets association 0.52 with neuroendocrine neoplasm (MONDO_0019496)","Gastric & gastro-oesophageal junction cancer: Open Targets association 0.52 with gastric cancer (MONDO_0001056)","Ovarian cancer: Open Targets association 0.51 with ovarian cancer (MONDO_0008170)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/foxp1/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"biliary-tract-cancer","kind":"cancer","name":"Biliary tract cancer (all types)","route":"/cancers/biliary-tract-cancer/"},{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"},{"id":"neuroendocrine","kind":"cancer","name":"Neuroendocrine tumours","route":"/cancers/neuroendocrine/"},{"id":"esophageal","kind":"cancer","name":"Oesophageal cancer","route":"/cancers/esophageal/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}