{"entity":{"id":"florence-duffaud","kind":"person","name":"Florence Duffaud","aka":[],"tldr":"Marseille oncologist who led REGOBONE, the trial that showed regorafenib delays progression in metastatic osteosarcoma and other bone sarcomas.","summary":"Florence Duffaud is a medical oncologist at Hôpital de la Timone in Marseille and a leader of the French Sarcoma Group. She was first author of the 2019 Lancet Oncology report of the osteosarcoma cohort of REGOBONE, the randomised phase 2 trial in which regorafenib improved progression-free survival compared with placebo in metastatic osteosarcoma after chemotherapy; other cohorts studied Ewing sarcoma, chondrosarcoma and chordoma.","asOf":"2026-09-18","links":[],"tags":["sarcoma","trialist"],"related":[],"cancers":["osteosarcoma","ewing-sarcoma","chondrosarcoma","sarcoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":["ap-hm-timone"],"pathways":[],"terms":[],"trials":["regobone"],"people":[],"bottlenecks":[],"keyPapers":["paper-florence-duffaud-ann-oncol-2017","paper-florence-duffaud-lancet-oncol-2020","paper-florence-duffaud-lancet-oncol-2019"],"journals":[],"dependsOn":[],"notes":[],"role":"Medical oncologist, Hôpital de la Timone, Aix-Marseille University","institutionId":"ap-hm-timone","specialisms":["Bone sarcoma","Gastrointestinal stromal tumour","Kinase inhibitors in sarcoma"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Duffaud%5BAuthor%5D"}],"papers":[{"title":"Improved survival using specialized multidisciplinary board in sarcoma patients","journal":"Annals of Oncology","year":2017,"url":"https://doi.org/10.1093/annonc/mdx484","doi":"10.1093/annonc/mdx484","note":"Europe PMC author record matched by affiliation (Hôpital de la Timone, Assistance Publique-Hôpitaux de Marseille); 274 citations on Europe PMC."},{"title":"Cabozantinib in patients with advanced Ewing sarcoma or osteosarcoma (CABONE): a multicentre, single-arm, phase 2 trial","journal":"The Lancet Oncology","year":2020,"url":"https://doi.org/10.1016/s1470-2045(19)30825-3","doi":"10.1016/s1470-2045(19)30825-3","note":"Europe PMC author record matched by affiliation (Hôpital de la Timone, Assistance Publique-Hôpitaux de Marseille); 267 citations on Europe PMC."},{"title":"Efficacy and safety of regorafenib in adult patients with metastatic osteosarcoma: a non-comparative, randomised, double-blind, placebo-controlled, phase 2 study","journal":"The Lancet Oncology","year":2019,"url":"https://doi.org/10.1016/s1470-2045(18)30742-3","doi":"10.1016/s1470-2045(18)30742-3","note":"Europe PMC author record matched by affiliation (Hôpital de la Timone, Assistance Publique-Hôpitaux de Marseille); 266 citations on Europe PMC."}],"orcid":"0000-0002-2057-3557"},"route":"/people/florence-duffaud/","neighbours":{"cancer":[{"id":"chondrosarcoma","kind":"cancer","name":"Chondrosarcoma","route":"/cancers/chondrosarcoma/"},{"id":"ewing-sarcoma","kind":"cancer","name":"Ewing sarcoma","route":"/cancers/ewing-sarcoma/"},{"id":"osteosarcoma","kind":"cancer","name":"Osteosarcoma","route":"/cancers/osteosarcoma/"},{"id":"sarcoma","kind":"cancer","name":"Sarcomas (soft tissue, bone, GIST)","route":"/cancers/sarcoma/"}],"institution":[{"id":"ap-hm-timone","kind":"institution","name":"Hôpital de la Timone, Assistance Publique-Hôpitaux de Marseille","route":"/institutions/ap-hm-timone/"}],"trial":[{"id":"regobone","kind":"trial","name":"REGOBONE","route":"/trials/regobone/"}],"paper":[{"id":"paper-florence-duffaud-lancet-oncol-2020","kind":"paper","name":"Cabozantinib in patients with advanced Ewing sarcoma or osteosarcoma (CABONE): a multicentre, single-arm, phase 2 trial","route":"/key-papers/paper-florence-duffaud-lancet-oncol-2020/"},{"id":"paper-florence-duffaud-lancet-oncol-2019","kind":"paper","name":"Efficacy and safety of regorafenib in adult patients with metastatic osteosarcoma: a non-comparative, randomised, double-blind, placebo-controlled, phase 2 study","route":"/key-papers/paper-florence-duffaud-lancet-oncol-2019/"},{"id":"paper-florence-duffaud-ann-oncol-2017","kind":"paper","name":"Improved survival using specialized multidisciplinary board in sarcoma patients","route":"/key-papers/paper-florence-duffaud-ann-oncol-2017/"}]}}